Art

J-GLOBAL ID：201702223321063710   Reference number：17A0791152

Compound 48/80, a mast cell degranulator, causes oxidative damage by enhancing vitamin C synthesis via reduced glutathione depletion and lipid peroxidation through neutrophil infiltration in rat livers

肥満細胞脱顆粒因子である化合物48/80はラット肝臓において還元型グルタチオン枯渇および好中球浸潤を通じた脂質過酸化を経由したビタミンC合成の増強によって酸化的損傷を引き起こす

Author (6)： Ohta Yosihiji (Department of Chemistry, Fujita Health University School of Medicine) ,  Yashiro Koji (Department of Chemistry, Fujita Health University School of Medicine) ,  Ohashi Koji (Department of Clinical Biochemistry, Faculty of Medical Chemistry, Fujita Health University School of Health Sciences) ,  Horikoshi Yosuke (Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, Totorri University Faculty of Medicine) ,  Kusumoto Chiaki (Department of Gastroenterology, Nippon Kokan Fukuyama Hospital) ,  Matsura Tatsuya (Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, Totorri University Faculty of Medicine)
Material： Journal of Clinical Biochemistry and Nutrition  (JCBN)
Volume： 60  Issue： 3  Page： 187-198(J-STAGE)  Publication year： 2017 
JST Material Number： X0851A  ISSN： 0912-0009  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *mastocyte ,...
Semi thesaurus term： immunological reaction

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A0791152&from=J-GLOBAL&jstjournalNo=X0851A") }}

Author keywords (5)： compound 48/80 ,  mast cell degranulation ,  oxidative damage ,  neutrophil infiltration ,  rat liver

JST classification (2)： Biophylaxis and immune systems in general  (ED01010F) ,  Cell physiology in general  (EF02010S)

Substance index (5)： Compound 48-80 ,  Glutathione ,  Ascorbic Acid ,  NPC-14686 ,  Ketotifen

Reference (47)：

• 1 Baltzly R, Buck JS, de Beer EJ, Webb FL. A family of long-acting depressors. J Am Chem Soc 1979; 71: 1301-1305.
• 2 Enerbäck L, Lundin PM. Ultrastructure of mucosal mast cells in normal and compound 48/80-treated rats. Cell Tissue Res 1974; 150: 95-105.
• 3 Irman-Florjanc T, Erjavec F. Compound 48/80 and substance P induced release of histamine and serotonin from rat peritoneal mast cells. Agents Actions 1983; 13: 138-141.
• 4 Ohta Y, Kamiya Y, Imai Y, Arisawa T, Nakano H. A change in gastric mucosal ascorbic acid status with the formation, progression, and recovery of compound 48/80-induced acute gastric mucosal lesions in rats. J Nutr Sci Vitaminol (Tokyo) 2004; 50: 371-376.
• 5 Kamiya Y, Ohta Y, Imai Y, Arisawa T, Nakano H. A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats. World J Gastroenterol 2005; 11: 1324-1332.

Terms in the title (12)： 肥満細胞 ,  脱顆粒 ,  因子 ,  ラット ,  肝臓 ,  還元型グルタチオン ,  枯渇 ,  好中球浸潤 ,  脂質過酸化 ,  ビタミンC ,  増強 ,  酸化的損傷