Art

J-GLOBAL ID：201702226102772900   Reference number：17A0683735

Statins Regulate Runx2 Expression in Human Dental Pulp Cells

スタチンはヒトの歯髄細胞におけるRunx2の発現を制御する

Author (7)： KAMADA Aiko (Osaka Dental Univ., Osaka, JPN) ,  YOSHIKAWA Yoshihiro (Osaka Dental Univ., Osaka, JPN) ,  DOMAE Eisuke (Osaka Dental Univ., Osaka, JPN) ,  SHINTANI Tsuguo (Osaka Dental Univ., Osaka, JPN) ,  KIKUCHI Yuko (Osaka Dental Univ., Osaka, JPN) ,  YOSHIMOTO Hitoshi (Osaka Dental Univ., Osaka, JPN) ,  IKEO Takashi (Osaka Dental Univ., Osaka, JPN)
Material： Journal of Oral Tissue Engineering  (J Oral Tissue Eng)
Volume： 14  Issue： 3  Page： 157-163  Publication year： Mar. 30, 2017 
JST Material Number： L5068A  ISSN： 1348-9623  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *fibroblast ,...
Semi thesaurus term： BMP-2 ,...

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JST classification (1)： Basic dentistry(= odontology)  (GT01020O)

Substance index (2)： Simvastatin ,  Compactin

Reference (22)：

• 1) Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990; 343: 425-430.
• 2) Mundy GR. Statins and their potential for osteoporosis. Bone 2001; 29: 495- 497.
• 3) Song C, Guo Z, Ma Q, Chen Z, Liu Z, Jia H, Dang G. Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells. Biochem Biophys Res Commun 2003; 308: 458-462.
• 4) Fukuyama R, Fujita T, Azuma Y, Hirano A, Nakamuta H, Koida M, Komori T. Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling. Biochem Biophys Res Commun 2004; 315: 636- 642.
• 5) Izumo N, Fujita T, Nakamuta H, Koida M. Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. Methods Find Exp Clin Pharmacol 2001; 23: 389-394.

Terms in the title (5)： スタチン ,  ヒト ,  歯髄細胞 ,  Runx2 ,  発現