Art

J-GLOBAL ID：201702226534656899   Reference number：17A0151663

α-Defensin 5 gene expression is regulated by gut microbial metabolites

α-ディフェンシン5遺伝子の発現は腸内微生物の代謝産物によって調節される

Author (10)： SUGI Yutaka (Nihon Univ., Fujisawa, JPN) ,  TAKAHASHI Kyoko (Nihon Univ., Fujisawa, JPN) ,  KURIHARA Kenta (Nihon Univ., Fujisawa, JPN) ,  NAKANO Kou (Nihon Univ., Fujisawa, JPN) ,  KOBAYAKAWA Tetsuro (Nihon Univ., Fujisawa, JPN) ,  NAKATA Kazuaki (Nihon Univ., Fujisawa, JPN) ,  TSUDA Masato (Nihon Univ., Fujisawa, JPN) ,  HANAZAWA Shigemasa (Nihon Univ., Fujisawa, JPN) ,  HOSONO Akira (Nihon Univ., Fujisawa, JPN) ,  KAMINOGAWA Shuichi (Nihon Univ., Fujisawa, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 81  Issue： 2  Page： 242-248  Publication year： Feb. 2017 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： peptide ,...
Semi thesaurus term： *genetic regulation ,...

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JST classification (3)： Interaction between dissimilar organisms  (EE01050A) ,  Biophylaxis and immune systems in general  (ED01010F) ,  Gene expression  (EC02040Q)

Reference (33)：

• Ouellette AJ. Paneth cell alpha-defensins in enteric innate immunity. Cell Mol Life Sci. 2011;68:2215-2229.
• Gallo RL, Hooper LV. Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol. 2012;12:503-516.
• Ayabe T, Satchell DP, Wilson CL, et al. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol. 2000;1:113-118.
• Ayabe T, Satchell DP, Pesendorfer P, et al. Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002;277:5219-5228.
• Ghosh D, Porter E, Shen B, et al. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002;3:583-590.

Terms in the title (6)： ディフェンシン ,  遺伝子 ,  発現 ,  腸内微生物 ,  代謝産物 ,  調節