Art

J-GLOBAL ID：201702226916433423   Reference number：17A0500559

Serotonergic System Does Not Contribute to the Hypothermic Action of Acetaminophen

セロトニン作動系はアセトアミノフェンの体温低下作用に寄与しない

Author (5)： Fukushima Akihiro (Laboratory of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, Musashino University) ,  Sekiguchi Wakana (Laboratory of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, Musashino University) ,  Mamada Kizuku (Laboratory of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, Musashino University) ,  Tohma Yumi (Laboratory of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, Musashino University) ,  Ono Hideki (Laboratory of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, Musashino University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 2  Page： 227-233(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： *体温低下作用 ,...

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Author keywords (12)： acetaminophen ,  hypothermia ,  serotonin ,  fluoxetine ,  cyproheptadine ,  analgesia ,  acetaminophen ,  hypothermia ,  serotonin ,  fluoxetine ,  cyproheptadine ,  analgesia

JST classification (3)： Basic research of antipyretic analgesics  (GW03040H) ,  Animal physiology in general  (EJ02010E) ,  Central nervous system  (EJ12030F)

Substance index (5)： Serotonin ,  Acetaminophen ,  4-Chloro-DL-phenylalanine ,  Fluoxetine hydrochloride ,  Cyproheptadine hydrochloride

Reference (37)：

• 1) Courad JP, Besse D, Delchambre C, Hanoun N, Hamon M, Eschalier A, Caussade F, Cloarec A. Acetaminophen distribution in the rat central nervous system. Life Sci., 69, 1455-1464 (2001).
• 2) Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. Br. J. Clin. Pharmacol., 34, 79-81 (1992).
• 3) Davison C, Guy JL, Levitt M, Smith PK. The distribution of certain non-narcotic analgetic agents in the CNS of several species. J. Pharmacol. Exp. Ther., 134, 176-183 (1961).
• 4) Massey TE, Walker RM, McElligott TF, Racz WJ. Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound. Toxicology, 25, 187-200 (1982).
• 5) Pelissier T, Alloui A, Caussade F, Dubray C, Cloarec A, Lavarenne J, Eschalier A. Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: in vivo and in vitro evidence. J. Pharmacol. Exp. Ther., 278, 8-14 (1996).

Terms in the title (4)： セロトニン ,  アセトアミノフェン ,  体温 ,  低下作用