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J-GLOBAL ID：201702228471967804   Reference number：17A1491969

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock

時計における温度感受性基質と生成物の結合温度補償りん酸化の基礎をなす【Powered by NICT】

Author (17)： Shinohara Yuta (Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Koyama Yohei M. (Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Koyama Yohei M. (Laboratory for Computational Molecular Design, RIKEN Quantitative Biology Center, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan) ,  Koyama Yohei M. (Research and Development Project of Special Purpose Supercomputers for Drug Design, RIKEN Quantitative Biology Center, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan) ,  Ukai-Tadenuma Maki (Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Hirokawa Takatsugu (Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan) ,  Hirokawa Takatsugu (Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Kikuchi Masaki (Epigenetics Drug Discovery Unit, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan) ,  Yamada Rikuhiro G. (Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ukai Hideki (Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Fujishima Hiroshi (Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Umehara Takashi (Epigenetics Drug Discovery Unit, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan) ,  Umehara Takashi (PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan) ,  Tainaka Kazuki (Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) ,  Tainaka Kazuki (System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, 1 Asahimachi, Chuo-ku, Niigata 951-8585, Japan) ,  Ueda Hiroki R. (Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ueda Hiroki R. (Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)
Material： Molecular Cell  (Mol Cell)
Volume： 67  Issue： 5  Page： 783-798.e20  Publication year： 2017 
JST Material Number： W1167A  ISSN： 1097-2765  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Temperature compensation is a ...

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Thesaurus term： *temperature compensation ,  simulation ,  diurnal rhythm ,  screening(inspection) ,  mutagenesis ,  affinity ,  *phosphorylation ,  temperature dependence ,  *temperature-sensitivity ,  yeast ,  complex(substance) ,  *substrate(biochemistry) ,  variation(biology) ,  Mammalia
Semi thesaurus term： 分子動力学シミュレーション , 【Automatic Indexing@JST】

Author keywords (10)： circadian clock ,  temperature compensation ,  casein kinase 1 ,  phosphorylation ,  enzyme mechanisms ,  enzyme simulation ,  enzyme design ,  structural biology ,  system biology ,  synthetic biology

JST classification (1)： Animal physiology in general  (EJ02010E)

Terms in the title (7)： 時計 ,  温度感受性 ,  基質 ,  生成物 ,  温度補償 ,  りん酸化 ,  基礎