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J-GLOBAL ID:201702228832516821   Reference number:17A0111399

Induction of langerin+ Langerhans cell-like cells expressing reduced TLR3 from CD34+ cord blood cells stimulated with GM-CSF, TGF-β1, and TNF-α

GM-CSFや,TGF-β1,およびTNF-αで刺激したCD34+臍帯血細胞由来還元型TLR3を発現するランゲリン+ランゲルハンス細胞様細胞の誘導
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Material:
Volume: 37  Issue:Page: 271-281(J-STAGE)  Publication year: 2016 
JST Material Number: Z0236B  ISSN: 0388-6107  Document type: Article
Article type: 原著論文  Country of issue: Japan (JPN)  Language: ENGLISH (EN)
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Cell physiology in general  ,  Integument in general  ,  Biophylaxis and immune systems in general 
Reference (23):
  • 1 Allam JP, Peng WM, Appel T, Wenghoefer M, Niederhagen B, Bieber T, Berge S and Novak N (2008) Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. J Allergy Clin Immunol 121, 368-374.
  • 2 Angel CE, Lala A, Chen CJ, Edgar SG, Ostrovsky LL and Dunbar PR (2007) CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts. Int Immunol 19, 1271-1279.
  • 3 Caux C, Vanbervliet B, Massacrier C, Dezutter-Dambuyant C, de Saint-Vis B, Jacquet C, Yoneda K, Imamura S, Schmitt D and Banchereau J (1996) CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J Exp Med 184, 695-706.
  • 4 Collin M and Milne P (2016) Langerhans cell origin and regulation. Curr Opin Hematol 23, 28-35.
  • 5 de Jong MA, de Witte L, Taylor ME and Geijtenbeek TB (2010) Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function. J Immunol 185, 1633-1641.
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