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J-GLOBAL ID：201702230526906511   Reference number：17A0183340

CCR6⁺ MCAM⁺ Th17 Cell Numbers Increase in Patients with Psoriasis and Correlate with Disease Severity

CCR6⁺MCAM⁺Th17細胞数は乾癬患者において増加し,疾患重症度と相関する

Author (10)： KOBAYASHI Kae (Department of Dermatology, Showa University School of Medicine) ,  KOBAYASHI Kae (Department of Pathology, Showa University School of Medicine) ,  WATANABE Hideaki (Department of Dermatology, Showa University School of Medicine) ,  KAMIYAMA Taisuke (Department of Dermatology, Showa University School of Medicine) ,  SUEKI Hirohiko (Department of Dermatology, Showa University School of Medicine) ,  SASAKI Yosuke (Department of Pathology, Showa University School of Medicine) ,  YAMOCHI Toshiko (Department of Pathology, Showa University School of Medicine) ,  KOKAZE Akatsuki (Department of Public Health, Showa University School of Medicine) ,  IWAMOTO Sanju (Division of Physiology and Pathology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy) ,  TAKIMOTO Masafumi (Department of Pathology, Showa University School of Medicine)
Material： Showa University Journal of Medical Sciences  (Showa Univ J Med Sci)
Volume： 28  Issue： 2  Page： 173-181(J-STAGE)  Publication year： 2016 
JST Material Number： L1154A  ISSN： 0915-6380  CODEN： SUMSEG  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： Disease severity ,...

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Author keywords (5)： psoriasis ,  Th17 cells ,  CCR6 ,  MCAM ,  IL-17

JST classification (2)： Skin diseases  (GF03000Q) ,  Immunologic diseases,allergic diseases in general.  (GD04010C)

Reference (24)：

• 1) Stern RS, Nijsten T, Feldman SR, et al. Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction. J Investig Dermatol Symp Proc. 2004;9:136-139.
• 2) Gelfand JM, Weinstein R, Porter SB, et al. Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol. 2005;141:1537-1541.
• 3) Kurd SK, Gelfand JM. The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003-2004. J Am Acad Dermatol. 2009;60:218-224.
• 4) Mease PJ. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. Curr Opin Rheumatol. 2015;27:127-133.
• 5) Jullien D, Prinz JC, Nestle FO. Immunogenicity of biotherapy used in psoriasis: the science behind the scenes. J Invest Dermatol. 2015;135:31-38.

Terms in the title (4)： 乾癬 ,  患者 ,  疾患重症度 ,  相関