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J-GLOBAL ID：201702230717541446   Reference number：17A0934983

Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development

抗ウイルス薬開発のための新規標的としてのA型インフルエンザ核蛋白質と核外輸送蛋白質のCRM1を介する核輸出の阻害【Powered by NICT】

Author (10)： Chutiwitoonchai Nopporn (Viral Infectious Disease Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Mano Takafumi (Viral Infectious Disease Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Kakisaka Michinori (Viral Infectious Disease Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Sato Hirotaka (Viral Infectious Disease Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Kondoh Yasumitsu (Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Osada Hiroyuki (Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Kotani Osamu (Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan) ,  Yokoyama Masaru (Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan) ,  Sato Hironori (Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan) ,  Aida Yoko (Viral Infectious Disease Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan)
Material： Virology
Volume： 507  Page： 32-39  Publication year： 2017 
JST Material Number： H0793A  ISSN： 0042-6822  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： An anti-influenza compound, DP...

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Thesaurus term： *Proteins ,  *Viruses ,  *antiviral drug ,  antiviral action ,  docking ,  *influenza ,  *nucleoprotein ,  in vitro experiment ,  influenza virus ,  in silico ,  molecular mechanism ,  *nuclear export ,  *CRM1 ,  *nuclear export ,  *microorganism
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Influenza A virus ,  Nucleoprotein ,  Nuclear export protein ,  Nuclear export signal ,  Chromosome region maintenance 1

JST classification (1)： Virus biochemistry  (EG04030F)

Terms in the title (10)： 抗ウイルス薬 ,  開発 ,  標的 ,  A型インフルエンザ ,  核蛋白質 ,  核外輸送 ,  蛋白質 ,  CRM1 ,  核輸出 ,  阻害