Art

J-GLOBAL ID：201702230736866186   Reference number：17A0280362

Dietary glucosylceramides suppress tumor growth in a mouse xenograft model of head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide

食事性グルコシルセラミドは,セラミドの増加を通した新脈管形成の抑制により,頭頚部扁平上皮癌のマウス異種移植モデルにおいて腫瘍成長を抑制する

Author (11)： YAZAMA Hiroaki (Tottori Univ., Yonago, JPN) ,  KITATANI Kazuyuki (Tottori Univ., Yonago, JPN) ,  FUJIWARA Kazunori (Tottori Univ., Yonago, JPN) ,  KATO Misaki (Tottori Univ. Hospital Cancer Center, Yonago, JPN) ,  HASHIMOTO-NISHIMURA Mayumi (Tottori Univ. Hospital Cancer Center, Yonago, JPN) ,  KAWAMOTO Katsuyuki (Tottori Univ., Yonago, JPN) ,  HASEGAWA Kensaku (Tottori Univ., Yonago, JPN) ,  KITANO Hiroya (Tottori Univ., Yonago, JPN) ,  BIELAWSKA Alicja (Medical Univ. South Carolina, Charleston, USA) ,  BIELAWSKI Jacek (Medical Univ. South Carolina, Charleston, USA) ,  OKAZAKI Toshiro (Kanazawa Medical Univ., Uchinada, JPN)
Material： International Journal of Clinical Oncology  (Int J Clin Oncol)
Volume： 20  Issue： 3  Page： 438-446  Publication year： Jun. 2015 
JST Material Number： L3966A  ISSN： 1341-9625  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *cerebroside ,...
Semi thesaurus term： *Glucosylceramides ,...

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JST classification (2)： Experimental treatment for tumors  (GE02040Y) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Reference (39)：

• Jemal A et al (2007) Cancer statistics. CA Cancer J Clin 57(1):43-66
• Chaigneau L et al (2006) Induction chemotherapy in patients with head and neck cancer. Bull Cancer 93(7):677-682
• Her C (2001) Nasopharyngeal cancer and the Southeast Asian patient. Am Fam Physician 63(9):1776-1782
• Fujiwara K et al (2011) Inhibitory effects of dietary glucosylceramides on squamous cell carcinoma of the head and neck in NOD/SCID mice. Int J Clin Oncol 16(2):133-140
• Ideta R et al (2011) Orally administered glucosylceramide improves the skin barrier function by upregulating genes associated with the tight junction and cornified envelope formation. Biosci Biotechnol Biochem 75(8):1516-1523

Terms in the title (9)： 食事 ,  グルコシルセラミド ,  セラミド ,  脈管形成 ,  頭頚部扁平上皮癌 ,  マウス ,  異種移植 ,  モデル ,  腫瘍成長