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J-GLOBAL ID：201702231045454964   Reference number：17A1970166

Indirubin derivatives protect against endoplasmic reticulum stress-induced cytotoxicity and down-regulate CHOP levels in HT22 cells

インジルビン誘導体は小胞体ストレス誘発細胞毒性に対する保護とHT22細胞におけるCHOPレベルを下方制御する【Powered by NICT】

Author (11)： Kosuge Yasuhiro (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Saito Hiroaki (Laboratory of Bio-organic Chemistry, School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi, Chiba 274-8555, Japan) ,  Haraguchi Tatsuki (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Ichimaru Yoshimi (Laboratory of Bio-organic Chemistry, School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi, Chiba 274-8555, Japan) ,  Ohashi Sachiyo (Laboratory of Biochemistry, School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi, Chiba 274-8555, Japan) ,  Miyagishi Hiroko (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Miyagishi Hiroko (Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi 324-8501, Japan) ,  Kobayashi Shunsuke (Laboratory of Biochemistry, School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi, Chiba 274-8555, Japan) ,  Ishige Kumiko (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Miyairi Shinichi (Laboratory of Bio-organic Chemistry, School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi, Chiba 274-8555, Japan) ,  Ito Yoshihisa (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 27  Issue： 23  Page： 5122-5125  Publication year： 2017 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Indirubin and its derivatives ...

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Thesaurus term： *ER stress ,  Cell Death ,  *cytotoxicity ,  *Endoplasmic Reticulum ,  pathogenesis ,  *Down-Regulation ,  analogical material ,  anti-inflammatory action ,  Western blotting ,  Hippocampal neuron ,  neuronal cell death ,  Neurodegenerative Diseases ,  *HT22 cell ,  bioassay ,  lactam ,  enone ,  polynuclear aromatic compound
Semi thesaurus term： *CHOP , 【Automatic Indexing@JST】

Author keywords (5)： Indirubin ,  Endoplasmic reticulum stress ,  CHOP ,  HT22 cells ,  Neurodegenerative diseases

JST classification (2)： Structure-activity relationship of drugs  (GV01050B) ,  Synthesis of drugs  (GV01030F)

Substance index (1)： Indirubin

Terms in the title (7)： インジルビン ,  誘導体 ,  小胞体ストレス ,  誘発 ,  細胞毒性 ,  HT22細胞 ,  下方制御