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J-GLOBAL ID：201702231648481829   Reference number：17A1953832

Effect of carbamazepine on expression of UDP-glucuronosyltransferase 1A6 and 1A7 in rat brain

ラット脳におけるUDP-グルクロノシルトランスフェラーゼ1A6と1A7の発現に対するカルバマゼピンの影響

Author (4)： Asai Yuki (Pharmaceutics, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan) ,  Sakakibara Yukiko (Pharmaceutics, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan) ,  Nadai Masayuki (Pharmaceutics, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan) ,  Katoh Miki (Pharmaceutics, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan)
Material： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metab Pharmacokinet (Web))
Volume： 32  Issue： 6  Page： 286-292  Publication year： 2017 
JST Material Number： U0705A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *brain ,...
Semi thesaurus term： *UDP glucuronosyltransferase 1A7 ,...

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Author keywords (5)： Uridine 5′-diphosphate-glucuronosyltransferases ,  Carbamazepine ,  Brain ,  Induction ,  Constitutive androstane receptor

JST classification (2)： Basic research of antiepileptics and anticonvulsants  (GW03060D) ,  Enzyme in general  (EB09010D)

Substance index (1)： Carbamazepine

Reference (40)：

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• Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, et al. Expression of UDP-glucuronosyltransferase 1 (UGT1) and glucuronidation activity toward endogenous substances in humanized UGT1 mouse brain. Drug Metab Dispos 2015;43:1071-6.
• King CD, Rios GR, Assouline JA, Tephly TR. Expression of UDPglucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate. Arch Biochem Biophys 1999;365:156-62.

Terms in the title (6)： ラット ,  脳 ,  UDP ,  グルクロノシルトランスフェラーゼ ,  発現 ,  カルバマゼピン