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J-GLOBAL ID：201702232205214052   Reference number：17A0389689

Tadalafil for male lower urinary tract symptoms improves endothelial function

タダラフィルは下部尿路症状を有する男性の内皮機能を改善する

Author (5)： Fukumoto Kazuhiko (Department of Urology, Kawasaki Medical School, Kurashiki, Okayama, Japan) ,  Nagai Atsushi (Department of Urology, Kawasaki Medical School, Kurashiki, Okayama, Japan) ,  Hara Ryoei (Department of Urology, Kawasaki Medical School, Kurashiki, Okayama, Japan) ,  Fujii Tomohiro (Department of Urology, Kawasaki Medical School, Kurashiki, Okayama, Japan) ,  Miyaji Yoshiyuki (Department of Urology, Kawasaki Medical School, Kurashiki, Okayama, Japan)
Material： International Journal of Urology (Web)  (Int J Urol (Web))
Volume： 24  Issue： 3  Page： 206-210  Publication year： 2017 
JST Material Number： U0707A  ISSN： 1442-2042  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： body mass index ,...

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Author keywords (5)： blood flow ,  lower urinary tract symptoms ,  reactive hyperemia index ,  tadalafil ,  vascular endothelium

JST classification (1)： Drug therapy(=pharmacotherapy)for urogenital diseases  (GM05020V)

Substance index (1)： Tadalafil

Reference (22)：

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• Takeda M, Nishizawa O, Imaoka T. Tadalafil for the treatment of lower urinary tract symptoms in japanese men with benign prostatic hyperplasia: results from a 12-week placebo-controlled dose-finding study with a 42-week open-label extension. LUTS 2012; 4: 110-9.
• Yokoyama O, Yoshida M, Kim SC. Tadalafil once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a randomized placebo- and tamsulosin-controlled 12-week study in Asian men. Int. J. Urol. 2013; 20: 193-201.
• Yokoyama O, Igawa Y, Takeda M. Tadalafil for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a review of clinical data in Asian men and an update on the mechanism of action. Ther. Adv. Urol. 2015; 7: 249-64.
• Morelli A, Sarchielli E, Comeglio P et al. Phosphodiesterase type 5 expression in human and rat lower urinary tract tissues and the effect of tadalafil on prostate gland oxygenation in spontaneously hypertensive rats. J. Sex. Med. 2011; 8: 2746-60.

Terms in the title (4)： タダラフィル ,  下部尿路症状 ,  男性 ,  内皮