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J-GLOBAL ID：201702232657425309   Reference number：17A0475072

E. coli mismatch repair enhances AT-to-GC mutagenesis caused by alkylating agents

大腸菌ミスマッチ修復はアルキル化剤によるATからGCへの変異誘発を増強する【Powered by NICT】

Author (9)： Nakano Kota (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan) ,  Yamada Yoko (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan) ,  Takahashi Eizo (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan) ,  Takahashi Eizo (Nihon Pharmaceutical University, Ina, Kita-Adachi-Gun, Saitama, 362-0806, Japan) ,  Arimoto Sakae (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan) ,  Okamoto Keinosuke (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan) ,  Negishi Kazuo (Nihon Pharmaceutical University, Ina, Kita-Adachi-Gun, Saitama, 362-0806, Japan) ,  Negishi Tomoe (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan) ,  Negishi Tomoe (Nihon Pharmaceutical University, Ina, Kita-Adachi-Gun, Saitama, 362-0806, Japan)
Material： Mutation Research. Genetic Toxicology and Environmental Mutagenesis  (Mutat Res Genet Toxicol Environ Mutagen)
Volume： 815  Page： 22-27  Publication year： 2017 
JST Material Number： W2380A  ISSN： 1383-5718  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Alkylating agents are known to...

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Thesaurus term： *variation(biology) ,  alkyl(aryl) transferase ,  methylation ,  *alkylating agent ,  wild type ,  base pair ,  beta-galactosidase ,  *mutagenesis ,  reverse mutation ,  DNA ,  gene deficiency ,  *mismatch repair
Semi thesaurus term： MutSDNAミスマッチ修復蛋白質 ,  変異頻度 ,  エチル化 , 【Automatic Indexing@JST】

Author keywords (7)： O ⁴-alkylthymine ,  Mismatch repair (MMR) ,  E. coli ,  O ⁶-alkylguanine-DNA alkyltransferase (AGT) ,  Nucleotide excision repair (NER) ,  Mutagenesis ,  Mutagenic repair

JST classification (4)： Molecular genetics in general  (EC02010J) ,  Genetic variation  (EC01030Y) ,  Toxicity of organic compounds  (GZ02030Y) ,  Carcinogenic mechanisms and factors  (GE02020C)

Terms in the title (6)： 大腸菌 ,  ミスマッチ修復 ,  アルキル化剤 ,  GC ,  変異誘発 ,  増強