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J-GLOBAL ID：201702234336346394   Reference number：17A1184343

First-line ceritinib versus platinum-based chemotherapy in advanced ALK-rearranged non-small-cell lung cancer (ASCEND-4): a randomised, open-label, phase 3 study

進行ALK再配列肺非小細胞癌(ASCEND 4)における最初の線ceritinib対白金ベース化学療法:無作為化,非盲検,第3相試験【Powered by NICT】

Author (23)： Soria Jean-Charles (University Paris-Sud, Orsay, France) ,  Soria Jean-Charles (Institut Gustave Roussy, Villejuif, France) ,  Tan Daniel S W (National Cancer Centre Singapore and Genome Institute of Singapore, Singapore) ,  Chiari Rita (Azienda Ospedale Perugia, Perugia, Italy) ,  Wu Yi-Long (Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Paz-Ares Luis (University Hospital Virgen del RocioDoce de Octubre, Universidad Complutense & CNIO, Madrid, Spain) ,  Wolf Juergen (University Hospital Cologne, Cologne, Germany) ,  Geater Sarayut L (Songklanagarind Hospital, Songkla, Thailand) ,  Orlov Sergey (State Pavlov Medical University, St Petersburg, Russia) ,  Cortinovis Diego (Az. Ospedaliera San Gerardo, Monza, Italy) ,  Yu Chong-Jen (National Taiwan University Hospital, Taipei, Taiwan) ,  Hochmair Maximillian (Respiratory Oncology Unit, Department of Respiratory and Critical Care Medicine, Otto-Wagner-Spital, Vienna, Austria) ,  Cortot Alexis B (CHU de LILLE, Lille, France) ,  Tsai Chun-Ming (Taipei Veterans General Hospital, Taipei, Taiwan) ,  Moro-Sibilot Denis (Hopital Albert Michallon, Grenoble, France) ,  Campelo Rosario G (University Hospital A Coruna, La Coruna, Spain) ,  McCulloch Tracey (Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA) ,  Sen Paramita (Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA) ,  Dugan Margaret (Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA) ,  Pantano Serafino (Novartis Pharma AG, Basel, Switzerland) ,  Branle Fabrice (Novartis Pharma AG, Basel, Switzerland) ,  Massacesi Cristian (Novartis Pharma AG, Basel, Switzerland) ,  de Castro Gilberto (Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Brazil)
Material： Lancet
Volume： 389  Issue： 10072  Page： 917-929  Publication year： 2017 
JST Material Number： B0673A  ISSN： 0140-6736  CODEN： LANCA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The efficacy of ceritinib in p...

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Thesaurus term： *phase 3 study ,  Anemia ,  *non-small cell lung cancer ,  nausea ,  patient ,  vomiting ,  Safety ,  *drug therapy ,  Diarrhea ,  evaluation criterion ,  platinum complex ,  antitumor drug ,  ammine complex ,  chloro complex ,  adverse reaction
Semi thesaurus term： cisplatin ,  carboplatin ,  有害事象 ,  無増悪生存期間 , 【Automatic Indexing@JST】

JST classification (3)： Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G) ,  Clinical application of drugs acting on digestive system  (GW09020B) ,  Medical information processing  (JE15030Q)

Substance index (1)： Pemetrexed

Terms in the title (7)： ALK ,  再配列 ,  肺非小細胞癌 ,  白金 ,  化学療法 ,  盲 ,  第3相試験