Art

J-GLOBAL ID：201702234388865182   Reference number：17A0223345

Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia

慢性低血糖症回避による2型糖尿病における低血糖症に対する視床下部-下垂体-副腎の応答の回復

Author (14)： Tsuda Shin-ichi (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Konishi Kazunori (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Otoda Toshiki (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Nagai Takako (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Takeda-Watanabe Ai (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Kanasaki Megumi (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Kitada Munehiro (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Kitada Munehiro (Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Japan) ,  Nakagawa Atsushi (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Nishizawa Makoto (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Kanasaki Keizo (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Kanasaki Keizo (Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Japan) ,  Koya Daisuke (Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan) ,  Koya Daisuke (Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Japan)
Material： Internal Medicine (Web)  (Intern Med (Web))
Volume： 55  Issue： 23  Page： 3471-3473(J-STAGE)  Publication year： 2016 
JST Material Number： U0033A  ISSN： 1349-7235  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： DPP-IV inhibitor ,...

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Author keywords (4)： hypoglycemia ,  insulin ,  DPP-4 inhibitor ,  hypothalamic-pituitary-adrenal

JST classification (1)： Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (1)： Sitagliptin

Reference (5)：

• 1. Gerich JE, Mokan M, Veneman T, Korytkowski M, Mitrakou A. Hypoglycemia unawareness. Endocr Rev 12: 356-371, 1991.
• 2. Fanelli CG, Epifano L, Rambotti AM, et al. Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM. Diabetes 42: 1683-1689, 1993.
• 3. Borg MA, Borg WP, Tamborlane WV, Brines ML, Shulman GI, Sherwin RS. Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats. Diabetes 48: 584-587, 1999.
• 4. George SA, Khan S, Briggs H, Abelson JL. CRH-stimulated cortisol release and food intake in healthy, non-obese adults. Psychoneuroendocrinology 35: 607-612, 2010.
• 5. Epel E, Lapidus R, McEwen B, Brownell K. Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinology 26: 37-49, 2001.

Terms in the title (9)： 慢性 ,  低血糖症 ,  回避 ,  2型糖尿病 ,  視床下部 ,  下垂体 ,  副腎 ,  応答 ,  回復