Art

J-GLOBAL ID：201702235318060467   Reference number：17A1961363

Liposomalization of oxaliplatin induces skin accumulation of it, but negligible skin toxicity

オキサリプラチンのリポソーム化は皮膚蓄積のを誘導するが,皮膚毒性をnegligible【Powered by NICT】

Author (9)： Nishida Kentaro (Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Kashiwagi Misaki (Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Shiba Shunsuke (Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Muroki Kiwamu (Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Ohishi Akihiro (Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan) ,  Doi Yusuke (Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan) ,  Ando Hidenori (Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan) ,  Ishida Tatsuhiro (Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan) ,  Nagasawa Kazuki (Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan)
Material： Toxicology and Applied Pharmacology  (Toxicol Appl Pharmacol)
Volume： 337  Page： 76-84  Publication year： 2017 
JST Material Number： H0532A  ISSN： 0041-008X  CODEN： TXAPA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Liposomalization causes altera...

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Thesaurus term： platinum ,  pharmacokinetics ,  antitumor action ,  macrophage ,  quality of life ,  antitumor drug ,  morphology ,  targeting ,  *liposome ,  inflammation
Semi thesaurus term： PEG化 ,  結腸直腸癌 ,  腫瘍組織 ,  *皮膚毒性 ,  *オキサリプラチン , 【Automatic Indexing@JST】

Author keywords (5)： Skin toxicity ,  Hand-foot syndrome ,  PEGylated liposome ,  Oxaliplatin ,  Doxorubicin

JST classification (2)： Toxicity of organic compounds  (GZ02030Y) ,  Cell physiology in general  (EF02010S)

Terms in the title (6)： オキサリプラチン ,  リポソーム ,  皮膚 ,  蓄積 ,  誘導 ,  皮膚毒性