Art

J-GLOBAL ID：201702236122784822   Reference number：17A0004381

Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (flngolimod) in NC/Nga mice

NC/Ngaマウスにおける新規免疫抑制剤FTY720軟膏(フィンゴリモド)を用いたダニ誘発難治性皮膚炎治療的アプローチ

Author (11)： Tsuji Takumi (Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Okuno Satoshi (Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Kuroda Ayano (Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Hamazaki Junya (Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Chikami Takuma (Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Sakurai Sakura (Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Yoshida Yuya (Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Banno Rie (Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Fujita Tetsuro (Research Institute for Production and Development) ,  Kohno Takeyuki (Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University) ,  Kohno Takeyuki (Research Institute for Production and Development)
Material： Allergology International  (Allergol Int)
Volume： 65  Issue： 2  Page： 172-179(J-STAGE)  Publication year： 2016 
JST Material Number： L6446A  ISSN： 1323-8930  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *immunosuppressant ,...
Semi thesaurus term： immunological reaction ,...

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Author keywords (1)： Atopic dermatitis; Epidermal barrier function; Filaggrin; FTY720 ointment; NC/Nga mice

JST classification (2)： Basic research of drugs acting on integumentum commune  (GW12010Y) ,  Treatment for immunologic diseases,allergic diseases.  (GD04030Y)

Substance index (3)： Fingolimod ,  Betamethasone ,  Tacrolimus

Reference (32)：

• 1.\tLeung DY. New insights into atopic dermatitis: role of skin barrier and immune dysregulation. Allergol Int 2013;62:151-61.
• 2.\tFujita T, Inoue K, Yamamoto S, Ikumoto T, Sasaki S, Toyama R, et al. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot 1994;47:208-15.
• 3.\tKiuchi M, Adachi K, Kohara T, Minoguchi M, Hanano T, Aoki Y, et al. Synthesis\nand immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols. J Med Chem 2000;43:2946-61.\n
• 4.\tTsunemi S, Iwasaki T, Kitano S, Imado T, Miyazawa K, Sano H. Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model. Clin Immunol 2010;136:197-204.
• 5.\tKohno T, Tsuji T, Hirayama K, Iwatsuki R, Hirose M, Watabe K, et al. A novel immunomodulator, FTY720, prevents development of experimental autoim- mune myasthenia gravis in C57BL/6 mice. Biol Pharm Bull 2005;28:736-9.

Terms in the title (9)： NC ,  マウス ,  免疫抑制剤 ,  FTY720 ,  軟膏 ,  フィンゴリモド ,  誘発 ,  皮膚炎 ,  治療