Art
J-GLOBAL ID：201702237318464583   Reference number：17A0431607

Computation-Assisted Disconnection Approach for the Synthesis of Neoantimycins, 15-Membered Macrocyclic Depsipeptides

ネオアンチマイシン,15員環大環状デプシペプチドの合成のための計算支援切断法
Author (8)：
YAMAKOSHI Shuhei

About YAMAKOSHI Shuhei

(Mitsubishi Tanabe Pharma Corp., Yokohama, JPN)

About Mitsubishi Tanabe Pharma Corp., Yokohama, JPN

, 
YAMAKOSHI Shuhei

About YAMAKOSHI Shuhei

(Hiroshima Univ., Hiroshima, JPN)

About Hiroshima Univ., Hiroshima, JPN

, 
OKAMOTO Masako

About OKAMOTO Masako

(Mitsubishi Tanabe Pharma Corp., Yokohama, JPN)

About Mitsubishi Tanabe Pharma Corp., Yokohama, JPN

, 
SAWAMOTO Hiroaki

About SAWAMOTO Hiroaki

(Mitsubishi Tanabe Pharma Corp., Yokohama, JPN)

About Mitsubishi Tanabe Pharma Corp., Yokohama, JPN

, 
ARAI Yuuki

About ARAI Yuuki

(Mitsubishi Tanabe Pharma Corp., Yokohama, JPN)

About Mitsubishi Tanabe Pharma Corp., Yokohama, JPN

, 
KAWANISHI Eiji

About KAWANISHI Eiji

(Mitsubishi Tanabe Pharma Corp., Yokohama, JPN)

About Mitsubishi Tanabe Pharma Corp., Yokohama, JPN

, 
SASAKI Michiko

About SASAKI Michiko

(Hiroshima Univ., Hiroshima, JPN)

About Hiroshima Univ., Hiroshima, JPN

, 
TAKEDA Kei

About TAKEDA Kei

(Hiroshima Univ., Hiroshima, JPN)

About Hiroshima Univ., Hiroshima, JPN


Material：
Current Organic Synthesis  (Curr Org Synth)

About Current Organic Synthesis


Volume： 14  Issue： 2  Page： 299-308  Publication year： 2017 
JST Material Number： W2205A  ISSN： 1570-1794  Document type： Article
Article type： 原著論文  Country of issue： Unknown (ARE)  Language： ENGLISH (EN)
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*macrocyclic compound

About macrocyclic compound

, 
*depsipeptide

About depsipeptide

, 
lactonization

About lactonization

, 
density functional method

About density functional method

, 
molecular dynamics

About molecular dynamics

, 
stability

About stability

, 
internuclear distance

About internuclear distance

, 
Cyclodepsipeptide

About Cyclodepsipeptide

, 
macrolactonization

About macrolactonization

, 
*retrosynthetic analysis

About retrosynthetic analysis

, 
Bioactive compounds

About Bioactive compounds

, 
conformational stability

About conformational stability


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
DFT calculation

About DFT calculation

, 
conformational stability

About conformational stability


JST classification (2)：
JST classification
Category name(code) classified by JST.
Peptides 
(CF10080G)

About Peptides

,  Electronic structure of molecules 
(BH05010Q)

About Electronic structure of molecules

Substance index (5)：
Substance index
Chemical Substance indexed to the Article.
Neoantimycin

About Neoantimycin

, 
(2S,3R)-2-(Boc-Amino)-3-(((2S,3S)-2-(2,2-dimethyl-3-oxo-4-(2-hydroxy-3-methylbutanoyloxy)-5-phenylpentanoyloxy)-3-methylpentanoyl)oxy)butyric acid

About (2S,3R)-2-(Boc-Amino)-3-(((2S,3S)-2-(2,2-dimethyl-3-oxo-4-(2-hydroxy-3-methylbutanoyloxy)-5-phenylpentanoyloxy)-3-methylpentanoyl)oxy)butyric acid

, 
(2S,13R,14S)-2-Isopropyl-5-benzyl-7,7,13-trimethyl-10-(1-methylpropyl)-14-(Boc-amino)-1,4,9,12-tetraoxacyclopentadecane-3,6,8,11,15-pentaone

About (2S,13R,14S)-2-Isopropyl-5-benzyl-7,7,13-trimethyl-10-(1-methylpropyl)-14-(Boc-amino)-1,4,9,12-tetraoxacyclopentadecane-3,6,8,11,15-pentaone

, 
N-[(2S,13R,14S)-2-Isopropyl-3,6,8,11,15-pentaoxo-5-benzyl-7,7,13-trimethyl-10-(1-methylpropyl)-1,4,9,12-tetraoxacyclopentadecane-14-yl]-2-benzyloxy-3-(formylamino)benzamide

About N-[(2S,13R,14S)-2-Isopropyl-3,6,8,11,15-pentaoxo-5-benzyl-7,7,13-trimethyl-10-(1-methylpropyl)-1,4,9,12-tetraoxacyclopentadecane-14-yl]-2-benzyloxy-3-(formylamino)benzamide

, 
N-[(2S,13R,14S)-2-Isopropyl-3,8,11,15-tetraoxo-5-benzyl-6-hydroxy-7,7,13-trimethyl-10-(1-methylpropyl)-1,4,9,12-tetraoxacyclopentadecane-14-yl]-2-benzyloxy-3-(formylamino)benzamide

About N-[(2S,13R,14S)-2-Isopropyl-3,8,11,15-tetraoxo-5-benzyl-6-hydroxy-7,7,13-trimethyl-10-(1-methylpropyl)-1,4,9,12-tetraoxacyclopentadecane-14-yl]-2-benzyloxy-3-(formylamino)benzamide

Terms in the title (5)：
Terms in the title
Keywords automatically extracted from the title.
環状

About 環状

, 
デプシペプチド

About デプシペプチド

, 
計算

About 計算

, 
支援

About 支援

, 
切断法

About 切断法


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