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J-GLOBAL ID：201702237396530506   Reference number：17A0566014

Anti-hyperglycemic Effect of Long-Term Bis(hinokitiolato)zinc Complex ([Zn(hkt)₂]) Ingestion on Insulin Resistance and Pancreatic Islet Cells Protection in Type 2 Diabetic KK-A^y Mice

2型糖尿病KK-Ayマウスにおけるインスリン抵抗性および膵島細胞保護に対する長期ビス(ヒノキチオラト)亜鉛複合体([Zn(hkt)2])摂取の抗高血糖作用

Author (8)： Naito Yuki (Department of Analytical & Bioinorganic Chemistry, Division of Analytical & Physical Sciences, Kyoto Pharmaceutical University) ,  Yoshikawa Yutaka (Department of Analytical & Bioinorganic Chemistry, Division of Analytical & Physical Sciences, Kyoto Pharmaceutical University) ,  Yoshikawa Yutaka (Department of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Women’s University) ,  Shintani Michiko (Laboratory of Pathology, Department of Medical Biophysics, Kobe University Graduate School of Health Sciences) ,  Shintani Michiko (Department of Medical Technology, Faculty of Health Sciences, Kobe Tokiwa University) ,  Kamoshida Shingo (Laboratory of Pathology, Department of Medical Biophysics, Kobe University Graduate School of Health Sciences) ,  Kajiwara Naemi (Department of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Women’s University) ,  Yasui Hiroyuki (Department of Analytical & Bioinorganic Chemistry, Division of Analytical & Physical Sciences, Kyoto Pharmaceutical University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 3  Page： 318-326(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： KKAy mouse ,...

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Author keywords (12)： zinc complex ,  pancreas ,  islet ,  insulin resistance ,  diabetes mellitus ,  histopathological analysis ,  zinc complex ,  pancreas ,  islet ,  insulin resistance ,  diabetes mellitus ,  histopathological analysis

JST classification (1)： Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Substance index (2)： Bis(1-oxy-4-isopropylcycloheptane-2,4,6-triene-2-yloxy) zinc ,  Pioglitazone

Reference (34)：

• 1) Chimienti F. Zinc, pancreatic islet cell function and diabetes: new insights into an old story. Nutr. Res. Rev., 26, 1-11 (2013).
• 2) Krizkova S, Ryvolova M, Hrabeta J, Adam V, Stiborova M, Eckschlager T, Kizek R. Metallothioneins and zinc in cancer diagnosis and therapy. Drug Metab. Rev., 44, 287-301 (2012).
• 3) Sun JY, Jing MY, Weng XY, Fu LJ, Xu ZR, Zi NT, Wang JF. Effects of dietary zinc levels on the activities of enzymes, weights of organs, and the concentrations of zinc and copper in growing rats. Biol. Trace Elem. Res., 107, 153-166 (2005).
• 4) Kadowaki S, Munekane M, Kitamura Y, Hiromura M, Kamino S, Yoshikawa Y, Saji H, Enomoto S. Development of new zinc dithiosemicarbazone complex for use as oral antidiabetic agent. Biol. Trace Elem. Res., 154, 111-119 (2013).
• 5) Fujimoto S, Yasui H, Yoshikawa Y. Development of a novel antidiabetic zinc complex with an organoselenium ligand at the lowest dosage in KK-A^y mice. J. Inorg. Biochem., 121, 10-15 (2013).

Terms in the title (10)： 2型糖尿病 ,  KK-Ayマウス ,  インスリン抵抗性 ,  膵島細胞 ,  長期 ,  ビス ,  亜鉛 ,  複合体 ,  Zn ,  高血糖