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J-GLOBAL ID：201702237921191422   Reference number：17A0959468

Prophylactic Oral Administration of Magnesium Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through a Decrease of Colonic Accumulation of P2X7 Receptor-Expressing Mast Cells

マグネシウムの予防的経口投与はP2X7受容体発現肥満細胞の結腸蓄積を通してマウスにおけるデキストラン硫酸ナトリウム誘発性結腸炎を寛解させる

Author (6)： Ohbori Kenshi (Department of Environmental Biochemistry, Kyoto Pharmaceutical University) ,  Fujiwara Makiko (Department of Environmental Biochemistry, Kyoto Pharmaceutical University) ,  Ohishi Akihiro (Department of Environmental Biochemistry, Kyoto Pharmaceutical University) ,  Nishida Kentaro (Department of Environmental Biochemistry, Kyoto Pharmaceutical University) ,  Uozumi Yoshinobu (Technical Development Department, Ako Kasei Co., Ltd.) ,  Nagasawa Kazuki (Department of Environmental Biochemistry, Kyoto Pharmaceutical University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 7  Page： 1071-1077(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： P2X7 receptor ,...

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Author keywords (10)： magnesium ,  colitis ,  inflammatory bowel disease ,  mast cell ,  P2X7 receptor ,  magnesium ,  colitis ,  inflammatory bowel disease ,  mast cell ,  P2X7 receptor

JST classification (1)： Basic medicine on digestive system  (GH01020E)

Reference (38)：

• 1) Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet, 369, 1627-1640 (2007).
• 2) Podolsky DK. Inflammatory bowel disease. N. Engl. J. Med., 347, 417-429 (2002).
• 3) Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat. Rev. Immunol., 8, 458-466 (2008).
• 4) Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature, 448, 427-434 (2007).
• 5) Arseneau KO, Tamagawa H, Pizarro TT, Cominelli F. Innate and adaptive immune responses related to IBD pathogenesis. Curr. Gastroenterol. Rep., 9, 508-512 (2007).

Terms in the title (12)： マグネシウム ,  予防 ,  経口投与 ,  P2X7受容体 ,  発現 ,  肥満細胞 ,  結腸 ,  蓄積 ,  マウス ,  デキストラン硫酸ナトリウム ,  結腸炎 ,  寛解