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J-GLOBAL ID：201702240820457911   Reference number：17A1022482

Single CpG site methylation controls estrogen receptor gene transcription and correlates with hormone therapy resistance

単一CpG部位のメチル化はエストロゲン受容体遺伝子転写を制御し,ホルモン療法抵抗性と相関する【Powered by NICT】

Author (12)： Tsuboi Kouki (Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, 980-8575, Japan) ,  Nagatomo Takamasa (Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, 980-8575, Japan) ,  Gohno Tatsuyuki (Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, 980-8575, Japan) ,  Higuchi Toru (Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, 980-8575, Japan) ,  Sasaki Shunta (Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, 980-8575, Japan) ,  Fujiki Natsu (Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, 980-8575, Japan) ,  Kurosumi Masafumi (Department of Pathology, Saitama Cancer Center, Ina-machi, Saitama, 362-0806, Japan) ,  Takei Hiroyuki (Division of Breast Surgery, Saitama Cancer Center, Ina-machi, Saitama, 362-0806, Japan) ,  Yamaguchi Yuri (Resarch Institute for Clinical Oncology, Saitama Cancer Center, Ina-machi, Saitama, 362-0806, Japan) ,  Niwa Toshifumi (Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, 980-8575, Japan) ,  Hayashi Shin-ichi (Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, 980-8575, Japan) ,  Hayashi Shin-ichi (Center for Regulatory Epigenome and Diseases, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, 980-8575, Japan)
Material： Journal of Steroid Biochemistry & Molecular Biology  (Journal of Steroid Biochemistry and Molecular Biology)
Volume： 171  Page： 209-217  Publication year： 2017 
JST Material Number： C0595A  ISSN： 0960-0760  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Hormone therapy is the most ef...

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Thesaurus term： *hormonal therapy ,  breast tumor ,  aromatase inhibitor ,  *Methylation ,  patient ,  sensitivity ,  *estrogen receptor ,  promoter (genetics) ,  transcriptional activity ,  DNA Methylation ,  Disease Progression ,  breast cancer cell ,  Estrogen Receptor alpha ,  *CpG ,  Gonadal Steroid Hormones ,  hormone
Semi thesaurus term： sex hormone , 【Automatic Indexing@JST】

Author keywords (5)： Breast cancer ,  DNA methylation ,  Estrogen receptor alpha ,  Ets-2 ,  Hormone therapy resistance

JST classification (1)： Sex hormones  (EB08050O)

Terms in the title (7)： CPG ,  メチル化 ,  エストロゲン受容体 ,  遺伝子転写 ,  ホルモン療法 ,  抵抗性 ,  相関