Art

J-GLOBAL ID：201702242988321212   Reference number：17A0177472

Pharmacokinetics and pharmacodynamics of prasugrel in healthy Japanese subjects

健康な日本人におけるプラスグレルの薬物動態と薬理動態

Author (4)： Umemura Kazuo (Department of Pharmacology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu-shi, Shizuoka, 431-3192, Japan) ,  Ikeda Yasuhiko (Department of Pharmacology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu-shi, Shizuoka, 431-3192, Japan) ,  Ikeda Yasuhiko (Shin-nakagawa Hospital, 3901 Ikenoya, Izumi-ku, Yokohama-shi, Kanagawa, 245-0001, Japan) ,  Kondo Kazunao (Department of Pharmacology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi, 470-1192, Japan)
Material： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metab Pharmacokinet (Web))
Volume： 31  Issue： 4  Page： 285-291  Publication year： Aug. 2016 
JST Material Number： U0705A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： healthy subject ,...

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Author keywords (5)： Prasugrel ,  P2Y₁₂ receptor antagonist ,  Pharmacokinetics ,  Inhibition of platelet aggregation ,  Japanese healthy subjects

JST classification (1)： Basic research of drugs acting on blood and body fluid  (GW14010M)

Substance index (1)： CS-747

Reference (16)：

• Farid NA, Kurihara A, Wrighton SA. Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans. J Clin Pharmacol 2010;50:126-42.
• Niitsu Y, Jakubowski JA, Sugidachi A, Asai F. Pharmacology of CS-747 (prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity. Semin Thromb Hemost 2005;31:184-94.
• Hasegawa M, Sugidachi A, Ogawa T, Isobe T, Jakubowski JA, Asai F. Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor. Thromb Haemost 2005;94:593-8.
• Rehmel JL, Eckstein JA, Farid NA, Heim JB, Kasper SC, Kurihara A, et al. Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450. Drug Metab Dispos 2006;34:600-7.
• Jakubowski JA, Winters KJ, Naganuma H, Wallentin L. Prasugrel: a novel thienopyridine antiplatelet agent. A review of preclinical and clinical studies and the mechanistic basis for its distinct antiplatelet profile. Cardiovasc Drug Rev 2007;25:357-74.

Terms in the title (4)： 日本人 ,  プラスグレル ,  薬物動態 ,  薬理動態