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J-GLOBAL ID：201702243322953379   Reference number：17A0153061

Ursodeoxycholic Acid Ameliorates Intrahepatic Cholestasis Independent of Biliary Bicarbonate Secretion in Vil2^kd/kd Mice

ウルソデオキシコール酸はVil2^kd/^kdマウスにおける胆汁性重炭酸塩分泌とは無関係に肝内胆汁鬱滞を寛解させる

Author (6)： Hatano Ryo (Department of Molecular Physiology, College of Pharmaceutical Sciences, Ritsumeikan University) ,  Kawaguchi Kotoku (Department of Molecular Physiology, College of Pharmaceutical Sciences, Ritsumeikan University) ,  Togashi Fumitaka (Department of Molecular Physiology, College of Pharmaceutical Sciences, Ritsumeikan University) ,  Sugata Masato (Department of Molecular Physiology, College of Pharmaceutical Sciences, Ritsumeikan University) ,  Masuda Shizuka (Department of Molecular Physiology, College of Pharmaceutical Sciences, Ritsumeikan University) ,  Asano Shinji (Department of Molecular Physiology, College of Pharmaceutical Sciences, Ritsumeikan University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 1  Page： 34-42(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： protein ,...
Semi thesaurus term： ezrin ,...

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Author keywords (8)： ursodeoxycholic acid ,  cholestatic disease ,  primary sclerosing cholangitis ,  ezrin ,  ursodeoxycholic acid ,  cholestatic disease ,  primary sclerosing cholangitis ,  ezrin

JST classification (1)： Basic research of drugs acting on digestive system  (GW09010Q)

Substance index (1)： Ursodeoxycholic Acid

Reference (28)：

• 1) Kotb MA. Molecular mechanisms of ursodeoxycholic acid toxicity & side effects: ursodeoxycholic acid freezes regeneration & induces hibernation mode. Int. J. Mol. Sci., 13, 8882-8914 (2012).
• 2) Oelkers P, Kirby LC, Heubi JE, Dawson PA. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J. Clin. Invest., 99, 1880-1887 (1997).
• 3) Oelkers P, Dawson PA. Cloning and chromosomal localization of the human ileal lipid-binding protein. Biochim. Biophys. Acta, 1257, 199-202 (1995).
• 4) Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N. The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J. Biol. Chem., 280, 6960-6968 (2005).
• 5) Alrefai WA, Gill RK. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm. Res., 24, 1803-1823 (2007).

Terms in the title (7)： ウルソデオキシコール酸 ,  マウス ,  胆汁 ,  重炭酸塩 ,  分泌 ,  肝内胆汁鬱滞 ,  寛解