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J-GLOBAL ID：201702243451457617   Reference number：17A1464187

Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells

組織調節性T細胞の分化と蓄積に重要な転写因子としての変異Foxp3対立遺伝子を明らかにするBATFの解析【Powered by NICT】

Author (17)： Hayatsu Norihito (Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Miyao Takahisa (Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Tachibana Masashi (Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Murakami Ryuichi (Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Murakami Ryuichi (Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan) ,  Kimura Akihiko (Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Kato Takako (Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Kawakami Eiryo (Laboratory for Disease Systems Modeling, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Kawakami Eiryo (Disease Biology Group, RIKEN Medical Sciences Innovation Hub Program, Kanagawa 230-0045, Japan) ,  Endo Takaho A. (Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Setoguchi Ruka (Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Watarai Hiroshi (Division of Stem Cell Cellomics, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Sciences, The University of Tokyo, Tokyo 108-8639, Japan) ,  Nishikawa Takeshi (Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Yasuda Takuwa (Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Yoshida Hisahiro (Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Hori Shohei (Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Hori Shohei (Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan)
Material： Immunity
Volume： 47  Issue： 2  Page： 268-283.e9  Publication year： 2017 
JST Material Number： W1727A  ISSN： 1074-7613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Foxp3 controls the development...

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Thesaurus term： *variation(biology) ,  pathogenicity ,  patient ,  interaction ,  *allele ,  *regulatory T cell ,  DNA ,  inflammation ,  mutation ,  *transcription factor ,  lymphoid tissue ,  autoimmune disease ,  autoimmunity ,  cell physiology
Semi thesaurus term： *FoxP3 , 【Automatic Indexing@JST】

Author keywords (7)： autoimmunity ,  regulatory T cells ,  non-lymphoid tissues ,  Foxp3 ,  disease-causing mutation ,  DNA-binding specificity ,  BATF

JST classification (2)： Gene expression  (EC02040Q) ,  Cell division and proliferation  (EF02020D)

Terms in the title (10)： 組織 ,  調節性T細胞 ,  分化 ,  蓄積 ,  転写因子 ,  変異 ,  FoxP3 ,  対立遺伝子 ,  BATF ,  解析