Art

J-GLOBAL ID：201702244061889291   Reference number：17A0289043

PET imaging of activated macrophages in a rheumatoid arthritis murine model using a translocator protein ligand (¹⁸F-FEDAC)

トランスロケーター蛋白質リガンド(¹⁸F-FEDAC)を用いた関節リウマチミューリンモデルの活性化マクロファージのPETイメージング

Author (12)： CHUNG Seock-Jin (Seoul National Univ., Seoul, KOR) ,  YOON Hai-Jeon (Ewha Womans Univ. School of Medicine, Seoul, KOR) ,  YOUN Hyewon (Seoul National Univ., Seoul, KOR) ,  YOUN Hyewon (Seoul National Univ. Cancer Hospital, Seoul, KOR) ,  KIM Mi Jeong (Seoul National Univ., Seoul, KOR) ,  LEE Yun-Sang (Seoul National Univ., Seoul, KOR) ,  JEONG Jae Min (Seoul National Univ., Seoul, KOR) ,  XIE Lin (National Inst. Radiological Sci., Chiba, JPN) ,  CHUNG June-Key (Seoul National Univ., Seoul, KOR) ,  KANG Keon Wook (Seoul National Univ., Seoul, KOR) ,  ZHANG Ming-Rong (National Inst. Radiological Sci., Chiba, JPN) ,  CHEON Gi Jeong (Seoul National Univ., Seoul, KOR)
Material： JSMI Report  (日本分子イメージング学会機関誌)
Volume： 10  Issue： 1  Page： 49-52  Publication year： Dec. 22, 2016 
JST Material Number： F1448A  ISSN： 1882-6490  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *PET(tomography) ,...
Semi thesaurus term： *TSPO ,...

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JST classification (2)： Musculoskeletal system diagnosis  (GG02000M) ,  Basic research of diagnostic drugs  (GW20010P)

Substance index (1)： [¹⁸F]FEDAC

Reference (10)：

• Kinne RW, Stuhlmüller B, Palombo-Kinne E, et al. The role of macrophages in the pathogenesis of rheumatoid arthritis. Rheumatoid Arthritis: The New frontiers in Pathogenesis and Treatment. Oxford: Oxford University Press. 2000. 69-87.
• Rosado-de-Castro PH, Lopes de Souza SA, Alexandre D, et al. Rheumatoid arthritis: Nuclear Medicine state-of-the-art imaging. World J Orthop. 2014. 5 (3) : 312-8.
• Zavala F, Lenfant M. Benzodiazepines and PK11195 exert immunomodulating activities by binding on a specific receptor on macrophages. Ann N Y Acad Sci. 1987. 496: 240-9.
• Bazzichi L, Betti L, Giannaccini G, et al. Peripheral-type benzodiazepine receptors in human mononuclear cells of patients affected by osteoarthritis, rheumatoid arthritis or psoriasic arthritis. Clin Biochem. 2003. 36: 57-60.
• Papadopoulos V, Baraldi M, Guilarte TR, et al. Translocator protein (18kDa) : new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006. 27: 402-9.

Terms in the title (7)： 蛋白質 ,  リガンド ,  関節 ,  活性化 ,  マクロファージ ,  PET ,  イメージング