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J-GLOBAL ID：201702244334482408   Reference number：17A1454588

Quantitative Analysis of the Transporter-Mediated Drug-Drug Interaction Between Atorvastatin and Rifampicin Using a Stable Isotope-IV Method

安定同位体IV法を用いたアトルバスタチンとリファンピシン間のトランスポーターを介した薬物間相互作用の定量的解析【Powered by NICT】

Author (8)： Yamashita Shinji (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Hasegawa Tsubasa (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Tachihara Masaki (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Minami Keiko (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Higashino Haruki (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Togashi Kazutaka (Pharmaceutical Business Division, Sumika Chemical Analysis Service, Ltd., Osaka 554-0022, Japan) ,  Mutaguchi Kuninori (Pharmaceutical Business Division, Sumika Chemical Analysis Service, Ltd., Osaka 554-0022, Japan) ,  Kataoka Makoto (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan)
Material： Journal of Pharmaceutical Sciences  (J Pharm Sci)
Volume： 106  Issue： 9  Page： 2671-2677  Publication year： 2017 
JST Material Number： C0260B  ISSN： 0022-3549  CODEN： JPMSAE  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： This study aims to investigate...

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Thesaurus term： *isotope ,  clearance ,  *drug interaction ,  *stable isotope ,  *quantitative analysis ,  plasma concentration ,  intravenous administration ,  oral administration ,  individual specificity ,  pharmacokinetics ,  pharmacokinetic parameter ,  OATP1A2 ,  Solute Carrier Organic Anion Transporter Family Member 1b1
Semi thesaurus term： OATP ,  OATP1B1 ,  経口バイオアベイラビリティ , 【Automatic Indexing@JST】

Author keywords (7)： drug-drug interactions ,  systemic exposure ,  oral bioavailability ,  hepatic uptake ,  organic anion transporting polypeptide ,  stable isotope ,  interindividual difference

JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (1)： Atorvastatin

Terms in the title (6)： 安定同位体 ,  アトルバスタチン ,  リファンピシン ,  トランスポーター ,  薬物間相互作用 ,  定量的解析