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J-GLOBAL ID：201702246100499984   Reference number：17A1018293

Simulation of intra-ciliary diffusion suggests a novel role of primary cilia as a cell-signaling enhancer

繊毛内拡散のシミュレーションは,細胞シグナル伝達増強因子としての一次繊毛の新規な役割を示唆する

Author (2)： Takao Daisuke (Department of Molecular Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka, 411-8540, Japan) ,  Kamimura Shinji (Department of Biological Sciences, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo, 112-8551, Japan)
Material： Development, Growth & Differentiation  (Dev Growth Differ)
Volume： 59  Issue： 5  Page： 415-422  Publication year： Jun. 2017 
JST Material Number： W0832A  ISSN： 0012-1592  Document type： Article
Article type： 文献レビュー  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *cilium ,...
Semi thesaurus term： *primary cilium

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Author keywords (5)： cilia ,  diffusion ,  flagella ,  signaling ,  simulation

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological system models in general  (EL02010K)

Reference (35)：

• Basten, S. G. & Giles, R. H. 2013. Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis. Cilia 2, 6.
• Beck, C. & Uhl, R. 1994. On the localization of voltage-sensitive calcium channels in the flagella of Chlamydomonas reinhardtii. J. Cell Biol. 125, 1119-1125.
• Besschetnova, T. Y., Kolpakova-Hart, E., Guan, Y., Zhou, J., Olsen, B. R. & Shah, J. V. 2010. Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr. Biol. 20, 182-187.
• Boekhoff, I., Tareilus, E., Strotmann, J. & Breer, H. 1990. Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants. EMBO J. 9, 2453-2458.
• Breslow, D. K., Koslover, E. F., Seydel, F., Spakowitz, A. J. & Nachury, M. V. 2013. An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier. J. Cell Biol. 203, 129-147.

Terms in the title (8)： 繊毛 ,  拡散 ,  シミュレーション ,  細胞 ,  シグナル伝達 ,  増強因子 ,  一次繊毛 ,  役割