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J-GLOBAL ID：201702246154657121   Reference number：17A0223053

Structure-cytotoxicity relationship of methacrylate-based resin monomers as evaluated by an anti-oxidant responsive element-luciferase reporter assay

抗酸化剤応答配列-ルシフェラーゼレポーターアッセイにより評価されたメタクリル酸塩基盤レジンモノマーの化学構造-細胞毒性相関

Author (8)： EGASHIRA Miki (Department of Dental Material Science, School of Dentistry, Aichi-Gakuin University) ,  SUZUKI Takahiro (Department of Biochemistry, School of Dentistry, Aichi-Gakuin University) ,  ORIMOTO Ai (Department of Endodontics, School of Dentistry, Aichi-Gakuin University) ,  OBATA Tohru (Department of Bioorganic Chemistry, School of Pharmacy, Aichi-Gakuin University) ,  NAKAMURA Hiroshi (Department of Endodontics, School of Dentistry, Aichi-Gakuin University) ,  TANAKA Motohiro (Department of Bioorganic Chemistry, School of Pharmacy, Aichi-Gakuin University) ,  KANAMORI Takao (Department of Biochemistry, School of Dentistry, Aichi-Gakuin University) ,  KAWAI Tatsushi (Department of Dental Material Science, School of Dentistry, Aichi-Gakuin University)
Material： Dental Materials Journal  (Dent Mater J)
Volume： 35  Issue： 6  Page： 946-951(J-STAGE)  Publication year： 2016 
JST Material Number： Y0283A  ISSN： 0287-4547  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： luciferase assay ,...

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Author keywords (5)： Resin monomers ,  Methacrylate derivatives ,  Cytotoxicity ,  Anti-oxidant responsive element ,  Luciferase reporter assay

JST classification (4)： Dental prosthetic materials  (GT06000B) ,  Basic dentistry(= odontology)  (GT01020O) ,  Influence on animals  (EE05040R) ,  Gene expression  (EC02040Q)

Substance index (6)： Methacrylic acid ethyl ,  Methacrylic acid 2-hydroxyethyl ,  N-(2-hydroxypropyl)acrylamide ,  Methacrylic acid methyl ,  Phorbol 12-myristate 13-acetate ,  Methacrylic acid butyl

Reference (19)：

• 1) Shim JS, Watts DC. Residual monomer concentrations in denture-base acrylic resin after an additional, soft-liner, heat-cure cycle. Dent Mater 1999; 15: 296-300.
• 2) Celebi N, Yuzugullu B, Canay S, Yucel U. Effect of polymerization methods on the residual monomer level of acrylic resin denture base polymers. Polym Adv Technol 2008; 19: 201-206.
• 3) Yoshii E. Cytotoxic effects of acrylates and methacrylates: relationships of monomer structures and cytotoxicity. J Biomed Mater Res 1997; 37: 517-524.
• 4) Kurata S, Morishita K, Kawase T, Umemoto K. Cytotoxic effects of polybasic acids, poly(alkenoic acid)s, and the monomers with various functional groups on human pulp fibroblasts. Dent Mater J 2011; 30: 904-912.
• 5) Fukumoto I, Tamura A, Matsumura M, Miura H, Yui N. Potential of dental resins: 2-Hydroxyethyl methacrylate and its water-soluble oligomers have immunostimulatory effects. PLoS One 2013; 8: e82540.

Terms in the title (7)： 抗酸化剤応答配列 ,  評価 ,  メタクリル酸塩 ,  基盤 ,  化学構造 ,  細胞毒性 ,  相関