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J-GLOBAL ID：201702247460450246   Reference number：17A0988299

Structural and mechanistic insights into homocysteine degradation by a mutant of methionine γ-lyase based on substrate-assisted catalysis

基質支援触媒作用に基づくメチオニンγ-リアーゼの変異株によるホモシステイン分解への構造的および機構的洞察【Powered by NICT】

Author (9)： Sato Dan (Department of Applied Biology, Graduate School of Science Technology, Kyoto Institute of Technology, Kyoto, 606-8585, Japan) ,  Shiba Tomoo (Department of Applied Biology, Graduate School of Science Technology, Kyoto Institute of Technology, Kyoto, 606-8585, Japan) ,  Yunoto Shunsuke (Department of Applied Biology, Graduate School of Science Technology, Kyoto Institute of Technology, Kyoto, 606-8585, Japan) ,  Furutani Kazuo (Department of Applied Biology, Graduate School of Science Technology, Kyoto Institute of Technology, Kyoto, 606-8585, Japan) ,  Fukumoto Mitsuki (Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University, Okayama, 700-8530, Japan) ,  Kudou Daizou (Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University, Okayama, 700-8530, Japan) ,  Tamura Takashi (Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University, Okayama, 700-8530, Japan) ,  Inagaki Kenji (Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University, Okayama, 700-8530, Japan) ,  Harada Shigeharu (Department of Applied Biology, Graduate School of Science Technology, Kyoto Institute of Technology, Kyoto, 606-8585, Japan)
Material： Protein Science
Volume： 26  Issue： 6  Page： 1224-1230  Publication year： 2017 
JST Material Number： W2730A  ISSN： 0961-8368  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Methionine γ-lyse (MGL) cataly...

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Thesaurus term： reaction intermediate ,  Ammonia ,  *substrate (biochemistry) ,  desorption ,  crystal structure ,  *catalyst ,  *lyase ,  mercapto group ,  steric hindrance ,  thiol ,  interaction ,  *Genetic Variation ,  aliphatic amine ,  sulfide (organic) ,  aliphatic carboxylic acid ,  sulfur containing amino acid ,  primary amine
Semi thesaurus term： *variation(biology) ,  *触媒作用 , 【Automatic Indexing@JST】

Author keywords (5)： sulfur-containing amino acids ,  pyridoxal 5′-phosphate ,  site-directed mutagenesis ,  X-ray crystal structure analysis ,  substrate-assisted catalysis

JST classification (1)： Enzyme in general  (EB09010D)

Substance index (2)： Methionine ,  Homocysteine

Terms in the title (9)： 基質 ,  支援 ,  触媒作用 ,  メチオニン ,  リアーゼ ,  変異株 ,  ホモシステイン ,  分解 ,  洞察