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J-GLOBAL ID：201702248137153580   Reference number：17A1437318

Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1

機能高進mTORはIRF1の同時アップレギュレーションと前立腺癌細胞における神経内分泌分化を誘導する【Powered by NICT】

Author (8)： Kanayama Mayuko (Department of Urology, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Kanayama Mayuko (Laboratory of Animal Resources, Center for Disease Biology and Integrated Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Hayano Toshiya (Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Shiga, Japan) ,  Koebis Michinori (Laboratory of Animal Resources, Center for Disease Biology and Integrated Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Maeda Tatsuya (Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan) ,  Tabe Yoko (Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Horie Shigeo (Department of Urology, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Aiba Atsu (Laboratory of Animal Resources, Center for Disease Biology and Integrated Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan)
Material： Prostate
Volume： 77  Issue： 15  Page： 1489-1498  Publication year： 2017 
JST Material Number： T0088A  ISSN： 0270-4137  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： BACKGROUND: Neuroendocrine-dif...

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Thesaurus term： transcription factor ,  *prostatic tumor ,  gene ,  Mammalia ,  *up-regulation ,  in vitro experiment ,  human(primates) ,  mass spectrometry ,  cell proliferation ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  enzyme inhibitor ,  hemiacetal ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone
Semi thesaurus term： LNCaP細胞 ,  予後不良 ,  *神経内分泌分化 ,  *前立腺癌細胞 ,  *インターフェロン制御因子1 , 【Automatic Indexing@JST】

Author keywords (4)： hyperactive mTOR ,  interferon regulatory factor 1 ,  LNCaP ,  NED

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Substance index (1)： Rapamycin

Terms in the title (7)： 機能高進 ,  mTOR ,  IRF1 ,  アップレギュレーション ,  前立腺癌細胞 ,  神経内分泌分化 ,  誘導