Art

J-GLOBAL ID：201702249787535240   Reference number：17A1475118

Molecular biology and treatment of CML

CMLの分子病態と治療

Author (1)： KIMURA SHIN'YA (佐賀大学医学部 血液・呼吸器・腫瘍内科)
Material： 臨床血液  (Japanese Journal of Clinical Hematology)
Volume： 58  Issue： 10  Page： 1920-1930(J-STAGE)  Publication year： 2017 
JST Material Number： Z0688A  ISSN： 0485-1439  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *chronic myeloid leukemia ,...
Semi thesaurus term： new drug development ,...

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Author keywords (8)： Chronic myeloid leukemia ,  BCR-ABL ,  ABL tyrosine kinase inhibitor ,  Stop TKI ,  Chronic myeloid leukemia ,  BCR-ABL ,  ABL tyrosine kinase inhibitor ,  Stop TKI

JST classification (2)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Treatment for tumors in general  (GE03031L)

Substance index (5)： Imatinib ,  Dasatinib ,  Nilotinib ,  SKI-606 ,  Ponatinib

Reference (48)：

• 1) Gonfloni S. Defying c-Abl signaling circuits through small allosteric compounds. Front Genet. 2014; 5; 1-6.
• 2) Wang JY. Regulation of cell death by the abl tyrosine kinase. Oncogene. 2000; 19: 5643-5650.
• 3) Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood. 2000; 96: 3343-3356.
• 4) McWhirter JR, Galasso DL, Wang JY et al. A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins. Mol Cell Biol. 1993; 13: 7587-7595.
• 5) Laurent E, Talpaz M, Kantarjian H, Kurzrock R. The BCR gene and Philadelphia chromosome-positive leukemogenesis. Cancer Res. 2001; 61: 2343-2355.

Terms in the title (3)： CML ,  分子病態 ,  治療