Art

J-GLOBAL ID：201702249893965192   Reference number：17A0495882

2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A₂ inhibitors

選択的カルシウム非依存性ホスホリパーゼA₂阻害剤としてのジペプチドに基づく2-オキソアミド

Author (8)： Smyrniotou Anneta (Chemical Laboratories, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece) ,  Kokotou Maroula G. (Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece) ,  Kokotou Maroula G. (Department of Pharmacology and Department of Chemistry and Biochemistry, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0601, USA) ,  Mouchlis Varnavas D. (Department of Pharmacology and Department of Chemistry and Biochemistry, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0601, USA) ,  Barbayianni Efrosini (Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece) ,  Kokotos George (Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece) ,  Dennis Edward A. (Department of Pharmacology and Department of Chemistry and Biochemistry, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0601, USA) ,  Constantinou-Kokotou Violetta (Chemical Laboratories, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 25  Issue： 3  Page： 926-940  Publication year： Feb. 01, 2017 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *dipeptide ,  *enzyme inhibitor ,  phospholipase A2 ,  carboxamide ,  ketone ,  aromatic compound ,  phenol ether ,  chemical synthesis ,  keto acid ,  carboxylate(ester) ,  structure-activity relationship ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  primary amine ,  branched-chain amino acid ,  aminocarboxylic acid
Semi thesaurus term： *オキソアミド ,  *Phospholipase A2 Inhibitors

Author keywords (5)： Dipeptides ,  Inhibitors ,  Oxoamides ,  Phospholipase A₂ ,  Pseudodipeptides

JST classification (2)： Peptides  (CF10080G) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (22)： D-Alanine ,  D-Norleucine ,  Alanine ,  Isoleucine ,  Norleucine ,  Valine ,  Leucine ,  Glycine ,  GABA ,  N-(1,2-Dioxo-6-phenylhexyl)-L-Nle-Gly-OBu^t ,  N-[1,2-Dioxo-6-(2-naphthyl)hexyl]-L-Nle-Gly-OBu^t ,  N-[1,2-Dioxo-6-(4-methoxyphenyl)hexyl]-L-Nle-βAla-OBu^t ,  N-[1,2-Dioxo-6-(4-methoxyphenyl)hexyl]-L-Nle-γAbu-OBu^t ,  5-[N-[1,2-Dioxo-6-(4-methoxyphenyl)hexyl]-L-norleucylamino]pentanoic acid tert-butyl ester ,  N-[1,2-Dioxo-6-(2-naphthyl)hexyl]-L-Nle-Gly-OBzl ,  2-[[(S)-2-(1,2-Dioxo-6-phenylhexylamino)hexyl]oxy]acetic acid tert-butyl ester ,  2-[[(S)-2-[1,2-Dioxo-6-(4-methoxyphenyl)hexylamino]hexyl]oxy]acetic acid tert-butyl ester ,  N^α-[1,2-Dioxo-6-(4-methoxyphenyl)hexyl]-L-norleucinamide ,  N-[1,2-Dioxo-6-(4-methoxyphenyl)hexyl]-L-norleucine tert-butyl ester ,  N-[1,2-Dioxo-6-(4-methoxyphenyl)hexyl]-L-Nle-Gly-OBu^t ,  N-[1,2-Dioxo-6-(4-methoxyphenyl)hexyl]-L-Nle-γAbu-OBzl ,  N-[1,2-Dioxo-6-(4-methoxyphenyl)hexyl]-L-Nle-Gly-Gly-OBu^t

Terms in the title (3)： カルシウム非依存性ホスホリパーゼA2 ,  阻害剤 ,  ジペプチド