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J-GLOBAL ID：201702250286312864   Reference number：17A1426314

In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Mueller cell line

かんきつ植物及び生物活性代謝産物から分離したノビレチンのin vitroでの研究,ヒト網膜Mueller細胞株におけるゼラチナーゼ酵素活性と分子機構に対する阻害作用【Powered by NICT】

Author (7)： Miyata Yoshiki (Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan) ,  Nagase Terumasa (The fifth Department of Internal Medicine, Tokyo Medical University, 3-20-1 Ami, Ibaraki 300-0332, Japan) ,  Katsura Yoshiya (The fifth Department of Internal Medicine, Tokyo Medical University, 3-20-1 Ami, Ibaraki 300-0332, Japan) ,  Takahashi Hideyo (Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan) ,  Natsugari Hideaki (Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan) ,  Oshitari Tetsuta (Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan) ,  Kosano Hiroshi (Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan)
Material： Biomedicine & Pharmacotherapy  (Biomedicine and Pharmacotherapy)
Volume： 93  Page： 70-80  Publication year： 2017 
JST Material Number： A0845C  ISSN： 0753-3322  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Diabetic retinopathy (DR) is t...

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Thesaurus term： *metabolite ,  therapy ,  *retina ,  inflammation ,  angiogenesis ,  *in vitro experiment ,  gene expression ,  matrix metalloproteinase ,  *enzyme activity ,  tumor cell ,  apoptosis ,  *human(primates)
Semi thesaurus term： マトリックスメタロプロテイナーゼ9 ,  *ゼラチナーゼ , 【Automatic Indexing@JST】

Author keywords (5)： Nobiletin ,  Matrix metalloproteinase-9 ,  Mueller cells ,  Diabetic retinopathy ,  Structure-activity relationship

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Nobiletin

Terms in the title (14)： かんきつ ,  植物 ,  生物活性 ,  代謝産物 ,  ノビレチン ,  研究 ,  ヒト ,  網膜 ,  Mueller細胞 ,  株 ,  ゼラチナーゼ ,  酵素活性 ,  分子 ,  阻害作用