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J-GLOBAL ID：201702252562000023   Reference number：17A0016905

Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines

Bellis perennisの花からのアシル化オレアナン型トリテルペンサポニンはヒト消化管癌細胞系に対する抗増殖活性を示す

Author (17)： Ninomiya Kiyofumi (Pharmaceutical Research and Technology Institute, Kindai University, Higashi-osaka, Osaka, Japan) ,  Ninomiya Kiyofumi (Antiaging Center, Kindai University, Higashi-osaka, Osaka, Japan) ,  Motai Chiaki (Pharmaceutical Research and Technology Institute, Kindai University, Higashi-osaka, Osaka, Japan) ,  Motai Chiaki (Koshiro Co., Ltd., Osaka, Japan) ,  Nishida Eriko (Pharmaceutical Research and Technology Institute, Kindai University, Higashi-osaka, Osaka, Japan) ,  Kitagawa Niichiro (Pharmaceutical Research and Technology Institute, Kindai University, Higashi-osaka, Osaka, Japan) ,  Kitagawa Niichiro (Koshiro Co., Ltd., Osaka, Japan) ,  Yoshihara Kazuya (Pharmaceutical Research and Technology Institute, Kindai University, Higashi-osaka, Osaka, Japan) ,  Hayakawa Takao (Pharmaceutical Research and Technology Institute, Kindai University, Higashi-osaka, Osaka, Japan) ,  Muraoka Osamu (Pharmaceutical Research and Technology Institute, Kindai University, Higashi-osaka, Osaka, Japan) ,  Muraoka Osamu (Antiaging Center, Kindai University, Higashi-osaka, Osaka, Japan) ,  Li Xuezheng (Kyoto Pharmaceutical University, Kyoto, Japan) ,  Nakamura Seikou (Kyoto Pharmaceutical University, Kyoto, Japan) ,  Yoshikawa Masayuki (Kyoto Pharmaceutical University, Kyoto, Japan) ,  Matsuda Hisashi (Kyoto Pharmaceutical University, Kyoto, Japan) ,  Morikawa Toshio (Pharmaceutical Research and Technology Institute, Kindai University, Higashi-osaka, Osaka, Japan) ,  Morikawa Toshio (Antiaging Center, Kindai University, Higashi-osaka, Osaka, Japan)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 70  Issue： 3  Page： 435-451  Publication year： 2016 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *Asteraceae ,...
Semi thesaurus term： apoptotic cell death ,...

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Author keywords (7)： Daisy ,  Bellis perennis ,  Asteraceae ,  Anti-proliferative activity ,  Acylated oleanane-type triterpene saponin ,  Perennisaponin ,  Apoptosis

JST classification (3)： Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Plant biochemistry  (EH01050J)

Substance index (19)： Perennisaponin A ,  Perennisaponin B ,  Perennisaponin C ,  Perennisaponin D ,  Perennisaponin E ,  Perennisaponin F ,  Perennisaponin G ,  Perennisaponin H ,  Perennisaponin I ,  Perennisaponin J ,  Perennisaponin K ,  Perennisaponin L ,  Perennisaponin M ,  Perennisaponin N ,  Perennisaponin O ,  Perennisaponin P ,  Perennisaponin Q ,  Perennisaponin R ,  Perennisaponin S

Reference (29)：

• Morikawa T, Li X, Nishida E, Ito Y, Matsuda H, Nakamura S, Muraoka O, Yoshikawa M (2008) Perennisosides I-VII, acylated triterpene saponins with antihyperlipidemic activities from the flowers of Bellis perennis. J Nat Prod 71:828-835
• Yoshikawa M, Li X, Nishida E, Nakamura S, Matsuda H, Muraoka O, Morikawa T (2008) Medicinal flowers. XXI. Structures of perennisaponins A, B, C, D, E, and F, acylated oleanane-type triterpene oligoglycosides, from the flowers of Bellis perennis. Chem Pharm Bull 56:559-568
• Morikawa T, Li X, Nishida E, Nakamura S, Ninomiya K, Matsuda H, Oda Y, Muraoka O, Yoshikawa M (2010) Medicinal flowers. Part 29. Acylated oleanane-type triterpene bisdesmosides: perennisaponins G, H, I, J, K, L, and M with pancreatic lipase inhibitory activity from the flowers of Bellis perennis. Helv Chim Acta 93:573-586
• Morikawa T, Li X, Nishida E, Nakamura S, Ninomiya K, Matsuda H, Hamao M, Muraoka O, Hayakawa T, Yoshikawa M (2011) Medicinal flowers. XXXII. structures of oleanane-type triterpene saponins, perennisosides VIII, IX, X, XI, and XII, from the flowers of Bellis perennis. Chem Pharm Bull 59:889-895
• Morikawa T, Ninomiya K, Takamori Y, Nishida E, Yasue M, Hayakawa T, Muraoka O, Li X, Nakamura S, Yoshikawa M, Matsuda H (2015) Oleanane-type triterpene saponins with collagen synthesis-promoting activity from the flowers of Bellis perennis. Phytochemistry 116:203-212

Terms in the title (8)： 花 ,  アシル化 ,  オレアナン ,  トリテルペンサポニン ,  ヒト ,  消化管 ,  癌細胞 ,  抗増殖活性