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J-GLOBAL ID：201702254225619984   Reference number：17A1137973

Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells

熱ショック蛋白質70阻害剤は,LNCaP95前立腺癌細胞におけるアンドロゲン受容体発現を抑制する

Author (12)： Kita Kazuaki (Department of Urology, Osaka City University Medical School, Osaka, Japan) ,  Shiota Masayuki (Department of Pharmacology, Osaka City University Medical School, Osaka, Japan) ,  Shiota Masayuki (Department of Research Support Platform, Osaka City University Medical School, Osaka, Japan) ,  Tanaka Masako (Department of Applied Pharmacology and Therapeutics, Osaka City University Medical School, Osaka, Japan) ,  Otsuka Asuka (Department of Applied Pharmacology and Therapeutics, Osaka City University Medical School, Osaka, Japan) ,  Matsumoto Masaki (Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan) ,  Kato Minoru (Department of Urology, Osaka City University Medical School, Osaka, Japan) ,  Tamada Satoshi (Department of Urology, Osaka City University Medical School, Osaka, Japan) ,  Iwao Hiroshi (Shitennoji University, Habikino, Japan) ,  Miura Katsuyuki (Department of Applied Pharmacology and Therapeutics, Osaka City University Medical School, Osaka, Japan) ,  Nakatani Tatsuya (Department of Urology, Osaka City University Medical School, Osaka, Japan) ,  Tomita Shuhei (Department of Pharmacology, Osaka City University Medical School, Osaka, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 108  Issue： 9  Page： 1820-1827  Publication year： 2017 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *tumor cell ,...
Semi thesaurus term： VER155008 ,...

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Author keywords (5)： Androgen receptor splice variant 7 ,  castration-resistant prostate cancer ,  heat shock protein 70 ,  heat shock protein 70 inhibitor ,  Y-box binding protein 1

JST classification (2)： Urogenital tumors(=neoplasms)  (GM04000S) ,  Basic oncology in general  (GE02010R)

Substance index (2)： Enzalutamide ,  Quercetin

Reference (32)：

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin 2017; 67: 177-193.
• Denmeade SR, Isaacs JT. A history of prostate cancer treatment. Nat Rev Cancer 2002; 2: 389-96.
• Guo Z, Yang X, Sun F et al. A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res 2009; 69: 2305-13.
• Antonarakis ES, Lu C, Wang H et al. AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med 2014; 371: 1028-38.
• Qu Y, Dai B, Ye D et al. Constitutively active AR-V7 plays an essential role in the development and progression of castration-resistant prostate cancer. Sci Rep 2015; 5: 7654.

Terms in the title (5)： 熱ショック蛋白質70 ,  阻害剤 ,  前立腺癌細胞 ,  アンドロゲン受容体 ,  発現