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J-GLOBAL ID：201702254674343799   Reference number：17A0184766

Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection

Aspergillus fumigatus感染カイコモデルを用いた新抗真菌剤ASP2397の発見

Author (8)： NAKAMURA Ikuko (Astellas Pharma Inc., Ibaraki, JPN) ,  KANASAKI Ryuichi (Astellas Pharma Inc., Ibaraki, JPN) ,  YOSHIKAWA Koji (Astellas Pharma Inc., Ibaraki, JPN) ,  FURUKAWA Shigetada (Astellas Pharma Inc., Ibaraki, JPN) ,  FUJIE Akihiko (Astellas Pharma Inc., Ibaraki, JPN) ,  HAMAMOTO Hiroshi (Teikyo Univ. Inst. of Medical Mycology, Tokyo, JPN) ,  SEKIMIZU Kazuhisa (Teikyo Univ. Inst. of Medical Mycology, Tokyo, JPN) ,  SEKIMIZU Kazuhisa (Genome Pharmaceuticals Inst., Tokyo, JPN)
Material： Journal of Antibiotics (Web)  (J Antibiot (Web))
Volume： 70  Issue： 1  Page： 41-44 (WEB ONLY)  Publication year： Jan. 2017 
JST Material Number： U0320A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： silkworm ,...
Semi thesaurus term： ASP-2397 ,...

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JST classification (1)： Basic research of antibiotics acting on pathogenic organisms  (GX05020C)

Substance index (1)： AS-2488059

Reference (15)：

• Denning, D. W. Invasive aspergillosis. Clin. Infect. Dis. 26, 781-803, quiz 804-805 (1998).
• Yeghen, T. et al. Management of invasive pulmonary aspergillosis in hematology patients: a review of 87 consecutive cases at a single institution. Clin. Infect. Dis. 31, 859-868 (2000).
• Fukuda, T. et al. Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning. Blood 102, 827-833 (2003).
• Herbrecht, R. et al. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N. Engl. J. Med. 347, 408-415 (2002).
• Thompson, G. R. 3rd & Lewis, J. S. 2nd Pharmacology and clinical use of voriconazole. Expert Opin. Drug Metabol. Toxicol. 6, 83-94 (2010).

Terms in the title (6)： Aspergillus ,  感染 ,  カイコ ,  モデル ,  抗真菌剤 ,  発見