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J-GLOBAL ID：201702255134731265   Reference number：17A1445208

Heat-induced native dimerization prevents amyloid formation by variable domain from immunoglobulin light-chain REI

熱誘導天然二量体化は免疫グロブリン軽鎖REIの可変領域によるアミロイド形成を阻止する【Powered by NICT】

Author (13)： Nawata Marina (Graduate School of Medicine, Kobe University, Japan) ,  Tsutsumi Hirotaka (Graduate School of Medicine, Kobe University, Japan) ,  Kobayashi Yuta (Graduate School of Medicine, Kobe University, Japan) ,  Unzai Satoru (Protein Design Laboratory, Yokohama City University, Japan) ,  Mine Shouhei (National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan) ,  Nakamura Tsutomu (National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan) ,  Uegaki Koichi (National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan) ,  Kamikubo Hironari (Laboratory of Bioenergetics and Biophysics, Nara Institute of Science and Technology (NAIST), Ikoma, Japan) ,  Kataoka Mikio (Laboratory of Bioenergetics and Biophysics, Nara Institute of Science and Technology (NAIST), Ikoma, Japan) ,  Hamada Daizo (Graduate School of Medicine, Kobe University, Japan) ,  Hamada Daizo (Department of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Japan) ,  Hamada Daizo (Graduate School of Engineering, Kobe University, Japan) ,  Hamada Daizo (Center for Applied Structural Science (CASS), Kobe University, Japan)
Material： FEBS Journal  (FEBS J)
Volume： 284  Issue： 18  Page： 3114-3127  Publication year： 2017 
JST Material Number： B0206B  ISSN： 1742-464X  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Amyloid light-chain (AL) amylo...

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Thesaurus term： monomer ,  amyloidosis ,  thermal stability ,  deconvolution ,  *dimerization ,  aggregate ,  *amyloid ,  oligomerization ,  wild type ,  circular dichroism ,  *light chain ,  *dimer ,  folding(morphology)
Semi thesaurus term： アミロイド線維 ,  *アミロイド形成 , 【Automatic Indexing@JST】

Author keywords (5)： amyloid ,  dimer-monomer equilibrium ,  sedimentation velocity ,  small-angle X-ray scattering ,  X-ray crystallography

JST classification (1)： Enzyme in general  (EB09010D)

Terms in the title (6)： 誘導 ,  二量体化 ,  免疫グロブリン軽鎖 ,  可変領域 ,  アミロイド形成 ,  阻止