Art

J-GLOBAL ID：201702255294707598   Reference number：17A1306701

Effect of the antidiabetic agent pioglitazone on bone metabolism in rats

ラットにおける骨代謝に与える抗糖尿病薬,ピオグリタゾンの影響

Author (9)： Kanda Junkichi (Department of Clinical Pharmacotherapy, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan) ,  Izumo Nobuo (General Health Medical Center, Yokohama University of Pharmacy, 601 Matano-cho, Totuka-ku, Yokohama 245-0066, Japan) ,  Kobayashi Yoshiko (Department of Radiation Science, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan) ,  Onodera Kenji (Department of Clinical Pharmacotherapy and Pharmacy, Bethel Epilepsy Centre, 27-4 Minami, Hatamukaiyama, Kitahase, Iwanuma 989-2455, Japan) ,  Shimakura Taketoshi (Niigata Bone Science Institute, 761 Kizaki, Kita-ku, Niigata 950-3304, Japan) ,  Yamamoto Noriaki (Niigata Bone Science Institute, 761 Kizaki, Kita-ku, Niigata 950-3304, Japan) ,  Yamamoto Noriaki (Division of Orthopedic Surgery, Niigata Rehabilitation Hospital, 761 Kizaki, Kita-ku, Niigata 950-3304, Japan) ,  Takahashi Hideaki E. (Niigata Bone Science Institute, 761 Kizaki, Kita-ku, Niigata 950-3304, Japan) ,  Wakabayashi Hiroyuki (Department of Clinical Pharmacotherapy, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan)
Material： Journal of Pharmacological Sciences (Web)  (J Pharmacol Sci (Web))
Volume： 135  Issue： 1  Page： 22-28  Publication year： 2017 
JST Material Number： U0667A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *bone metabolism ,...
Semi thesaurus term： serodiagnosis ,...

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Author keywords (5)： Pioglitazone ,  Bone resorption ,  Osteoclast ,  Osteoblast ,  Rat

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Substance index (2)： Pioglitazone ,  2,4-Thiazolidinedione

Reference (45)：

• Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem. 1995;270:12953-12956.
• Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 1994;8: 1224-1234.
• Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994;79:1147-1156.
• Okuno A, Tamemoto H, Tobe K, et al. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest. 1998;101:1354-1361.
• Yamauchi T, Kamon J, Waki H, et al. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem. 2001;276:41245-41254.

Terms in the title (4)： ラット ,  骨代謝 ,  抗糖尿病薬 ,  ピオグリタゾン