Art

J-GLOBAL ID：201702256375164994   Reference number：17A1371024

Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood

クルクミンβ-D-グルクロニドは血中の高レベルの遊離型クルクミンを保つのに重要な役割を果たす

Author (9)： Ozawa Hitomi (Theravalues Corp.) ,  Imaizumi Atsushi (TheraBioPharma Inc.) ,  Sumi Yoshihiko (Theravalues Corp.) ,  Hashimoto Tadashi (TheraBioPharma Inc.) ,  Kanai Masashi (Department of Clinical Oncology, Kyoto University Hospital Cancer Center) ,  Makino Yuji (Faculty of Pharmacy, Musashino University) ,  Tsuda Takanori (College of Bioscience and Biotechnology, Chubu University) ,  Takahashi Nobuaki (Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University) ,  Kakeya Hideaki (Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 9  Page： 1515-1524(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...

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Author keywords (10)： free-form curcumin ,  conjugated curcumin ,  curcumin monoglucuronide ,  cancer ,  prodrug ,  free-form curcumin ,  conjugated curcumin ,  curcumin monoglucuronide ,  cancer ,  prodrug

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Curcumin ,  Curcumin β-D-glucuronide

Reference (50)：

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• 3) Sugiyama Y, Kawakishi S, Osawa T. Involvement of the beta-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin. Biochem. Pharmacol., 52, 519-525 (1996).
• 4) Wright JS. Predicting the antioxidant activity of curcumin and curcuminoids. J. Mol. Struct. THEOCHEM, 591, 207-217 (2002).
• 5) Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res., 23 (1A), 363-398 (2003).

Terms in the title (5)： クルクミン ,  グルクロニド ,  血 ,  高レベル ,  役割