Art

J-GLOBAL ID：201702257099284323   Reference number：17A0877034

Thrombospondin-1 expression may be implicated in liver atrophic mechanism due to obstructed portal venous flow

トロンボスポンジン-1の発現は門脈血流閉塞による肝委縮機構に関与している可能性がある

Author (11)： Hayashi Hiromitsu (Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Hayashi Hiromitsu (Department of Surgery, Saiseikai Kumamoto Hospital, Kumamoto, Japan) ,  Kuroki Hideyuki (Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Higashi Takaaki (Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Takeyama Hideaki (Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Yokoyama Naomi (Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Okabe Hirohisa (Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Nitta Hidetoshi (Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Beppu Toru (Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Takamori Hiroshi (Department of Surgery, Saiseikai Kumamoto Hospital, Kumamoto, Japan) ,  Baba Hideo (Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan)
Material： Hepatology Research  (Hepatol Res)
Volume： 47  Issue： 8  Page： 803-812  Publication year： Jul. 2017 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *thrombospondin-1 ,...

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Author keywords (4)： atrophic liver ,  obstructed portal flow ,  Smad signal ,  thrombospondin-1

JST classification (2)： Digestive system diseases  (GH03000W) ,  Proteins and peptides in general  (EB03010N)

Reference (20)：

• Hayashi H, Beppu T, Sugita H et al. Increase in the serum bile acid level predicts the effective hypertrophy of the nonembolized hepatic lobe after right portal vein embolization. World J Surg 2009; 33: 1933-40.
• Hayashi H, Beppu T, Sugita H et al. Serum HGF and TGF-β1 levels after right portal vein embolization. Hepatol Res 2010; 40: 311-7.
• Crawford SE, Stellmach V, Murphy-Ullrich JE et al. Thrombospondin-1 is a major activator of TGF-β1 in vivo. Cell 1998; 93: 1159-70.
• Adams JC. Thrombospondins: multifunctional regulators of cell interactions. Annu Rev Cell Dev Biol 2001; 17: 25-51.
• Kyriakides TR, Madauchlan S. The role of thrombospondins in wound healing, ischemia, and the foreign body reaction. J Cell Commun Signal 2009; 3: 215-25.

Terms in the title (6)： トロンボスポンジン-1 ,  発現 ,  門脈血流 ,  閉塞 ,  肝委縮 ,  可能性