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J-GLOBAL ID：201702257189522109   Reference number：17A0504251

Detailed analysis of targeted gene mutations caused by the Platinum-Fungal TALENs in Aspergillus oryzae RIB40 strain and a ligD disruptant

Aspergillus oryzae RIB40株およびligD破壊株におけるPlatinum-Fungal TALENによって引き起こされた遺伝子ターゲティング突然変異の詳細な解析

Author (9)： Mizutani Osamu (National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan) ,  Arazoe Takayuki (Graduate School of Agriculture, Meiji University, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan) ,  Toshida Kenji (National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan) ,  Hayashi Risa (National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan) ,  Ohsato Shuichi (Graduate School of Agriculture, Meiji University, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan) ,  Sakuma Tetsushi (Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan) ,  Yamamoto Takashi (Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan) ,  Kuwata Shigeru (Graduate School of Agriculture, Meiji University, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan) ,  Yamada Osamu (National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan)
Material： Journal of Bioscience and Bioengineering
Volume： 123  Issue： 3  Page： 287-293  Publication year： Mar. 2017 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *nuclease ,...
Semi thesaurus term： *Non-Homologous End-Joining repair ,...

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Author keywords (6)： Key words Aspergillus oryzae ,  Genome editing ,  Transcription activator-like effector nucleases ,  ligD ,  Large deletion ,  Nonhomologous end-joining

JST classification (2)： Research methods in biological sciences in general  (EA03010K) ,  Research methods in microbiology and virology in general  (EG02010V)

Reference (47)：

• Christian, M., Cermak, T., Doyle, E. L, Schmidt, C., Zhang, F., Hummel, A., Bogdanove, A. J., and Voytas, D. F.: Targeting DNA double-strand breaks with TAL effector nucleases, Genetics, 186, 757-761 (2010).
• Joung, J. K. and Sander, J. D.: TALENs: a widely applicable technology for targeted genome editing, Nat. Rev. Mol. Cell Biol., 14, 49-55 (2013).
• Sun, N. and Zhao, H.: Transcription activator-like effector nucleases (TALENs): a highly efficient and versatile tool for genome editing, Biotechnol. Bioeng., 110, 1811-1821 (2013).
• Sakuma, T., Ochiai, H., Kaneko, T., Mashimo, T., Tokumasu, D., Sakane, Y., Suzuki, K., Miyamoto, T., Sakamoto, N., Matsuura, S., and Yamamoto, T.: Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity, Sci. Rep., 3, 3379 (2013).
• Arazoe, T., Ogawa, T., Miyoshi, K., Yamato, T., Ohsato, S., Sakuma, T., Yamamoto, T., Arie, T., and Kuwata, S.: Tailor-made TALEN system for highly efficient targeted gene replacement in the rice blast fungus, Biotechnol. Bioeng., 112, 1335-1342 (2015).

Terms in the title (7)： Aspergillus ,  破壊 ,  株 ,  TALEN ,  遺伝子ターゲティング ,  突然変異 ,  解析