Art

J-GLOBAL ID：201702257433133076   Reference number：17A0221688

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

炎症性腸疾患における複数のインテグリン遺伝子の免疫活性化がゲノムワイド関連解析により明らかになった

Author (42)： DE LANGE Katrina M (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  MOUTSIANAS Loukas (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  LUO Yang (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  RICE Daniel L (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  GUTIERREZ-ACHURY Javier (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  JI Sun-Gou (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  ANDERSON Carl A (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  BARRETT Jeffrey C (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  LEE James C (Addenbrooke’s Hospital, Cambridge, GBR) ,  PARKES Miles (Addenbrooke’s Hospital, Cambridge, GBR) ,  LAMB Christopher A (Newcastle Univ., Newcastle-upon-Tyne, GBR) ,  LUO Yang (Harvard Medical School, Massachusetts, USA) ,  LUO Yang (Broad Inst., Harvard and MIT, Massachusetts, USA) ,  KENNEDY Nicholas A (Univ. Exeter, Exeter, GBR) ,  HEAP Graham (Univ. Exeter, Exeter, GBR) ,  AHMAD Tariq (Univ. Exeter, Exeter, GBR) ,  KENNEDY Nicholas A (Royal Devon and Exeter Foundation Trust, Exeter, GBR) ,  HEAP Graham (Royal Devon and Exeter Foundation Trust, Exeter, GBR) ,  AHMAD Tariq (Royal Devon and Exeter Foundation Trust, Exeter, GBR) ,  JOSTINS Luke (Univ. Oxford, Headington, GBR) ,  JOSTINS Luke (Univ. Oxford, St Aldates, GBR) ,  NIMMO Elaine R (Univ. Edinburgh, Edinburgh, GBR) ,  SATSANGI Jack (Univ. Edinburgh, Edinburgh, GBR) ,  LEES Charlie W (Univ. Edinburgh, Edinburgh, GBR) ,  EDWARDS Cathryn (Torbay Hospital, Torbay, GBR) ,  HENDERSON Paul (Univ. Edinburgh, Edinburgh, GBR) ,  WILSON David C (Univ. Edinburgh, Edinburgh, GBR) ,  HENDERSON Paul (Royal Hospital for Sick Children, Edinburgh, GBR) ,  MOWAT Craig (Ninewells Hospital and Medical School, Dundee, GBR) ,  SANDERSON Jeremy (St Thomas’ Hospital, London, GBR) ,  SIMMONS Alison (Univ. Oxford, Oxford, GBR) ,  UHLIG Holm (Univ. Oxford, Oxford, GBR) ,  WILSON David C (Royal Hospital for Sick Children, Edinburgh, GBR) ,  TREMELLING Mark (Norfolk and Norwich Univ. Hospital, Norwich, GBR) ,  HART Ailsa (St. Mark’s Hospital, Harrow, GBR) ,  MATHEW Christopher G (King’s Coll. London, London, GBR) ,  PRESCOTT Natalie J (King’s Coll. London, London, GBR) ,  MATHEW Christopher G (Univ. Witwatersrand, Johannesburg, ZAF) ,  NEWMAN William G (Manchester Academic Health Sci. Centre, Manchester, GBR) ,  NEWMAN William G (Univ. Manchester, Manchester, GBR) ,  HAWKEY Chris (Queens Medical Centre, Nottingham, GBR) ,  MANSFIELD John C (Newcastle Univ., Newcastle-upon-Tyne, GBR)
Material： Nature Genetics  (Nat Genet)
Volume： 49  Issue： 2  Page： 256-261  Publication year： Feb. 2017 
JST Material Number： W0430A  ISSN： 1061-4036  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： Genome-Wide Association Study ,  inflammation ,  *intestinal disease ,  *integrin ,  gene ,  *immunological reaction ,  human(primates) ,  meta-analysis ,  gene expression ,  missense mutation ,  risk
Semi thesaurus term： インテグリン遺伝子 ,  *Inflammatory Bowel Diseases ,  disease risk ,  *immune activation

JST classification (3)： Genetic variation  (EC01030Y) ,  Immunological reaction in general  (ED03010T) ,  Basic medicine on digestive system  (GH01020E)

Terms in the title (5)： 炎症性腸疾患 ,  インテグリン ,  遺伝子 ,  免疫活性化 ,  ゲノムワイド関連解析