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J-GLOBAL ID：201702258127917067   Reference number：17A1533275

CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element

多環芳香族炭化水素によるCYP3A4誘導の機序は,PXR結合因子におけるリファンピシンのそれとは異なる。

Author (10)： Aratsu Yusuke (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Aratsu Yusuke (Drug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan tobacco Inc.) ,  Odagiri Reo (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Shoji Rie (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Watanabe Kouki (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Kumagai Takeshi (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Shindo Sawako (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Sasaki Takamitsu (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Sasaki Takamitsu (Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizoka) ,  Nagata Kiyoshi (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University)
Material： Fundamental Toxicological Sciences (Web)  (Fundam Toxicol Sci (Web))
Volume： 4  Issue： 5  Page： 229-239(J-STAGE)  Publication year： 2017 
JST Material Number： U0596A  ISSN： 2189-115X  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cytochrome P450 ,...
Semi thesaurus term： *genetic regulation ,...

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Author keywords (6)： CYP3A4 induction ,  Pregnane X receptor ,  Rifampicin ,  Polycyclic aromatic hydrocarbons ,  Dibenz[ah]anthracene ,  PXR binding element

JST classification (3)： Basic biopharmacy  (GY01021U) ,  Interactions of drugs  (GV01070X) ,  Pharmacology of antibiotics in general  (GX05010R)

Substance index (2)： Anthracene ,  Rifampin

Reference (27)：

• Bertilsson, G., Heidrich, J., Svensson, K., Asman, M., Jendeberg, L., Sydow-Bäckman, M., Ohlsson, R., Postlind, H., Blomquist, P. and Berkenstam, A. (1998): Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl. Acad. Sci. USA, 95, 12208-12213.
• Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., Van Meter, C.M., Ong, E.S. and Evans, R.M. (1998): SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev., 12, 3195-3205.
• Drocourt, L., Ourlin, J.C., Pascussi, J.M., Maurel, P. and Vilarem, M.J. (2002): Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J. Biol. Chem., 277, 25125-25132.
• Elias, A., High, A.A., Mishra, A., Sien, S., Wu, J., Peng, J. and Chen, T. (2014): Identification and characterization of phosphorylation sites within the pregnane X receptor protein. Biochem. Pharmacol., 87, 360-370.
• EMA (2012): Guideline on the investigation of drug interactions. Guid. Doc., 44, 59.

Terms in the title (6)： 多環芳香族炭化水素 ,  CYP3A4 ,  誘導 ,  PXR ,  因子 ,  リファンピシン