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J-GLOBAL ID：201702258483973896   Reference number：17A0681745

Protein kinase C-δ signaling regulates glucagon secretion from pancreatic islets

蛋白質キナーゼCδのシグナル伝達は膵島からのグルカゴン分泌を制御する

Author (8)： Yamamoto Kiyotake (Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Mizuguchi Hiroyuki (Department of Molecular Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Tokashiki Natsumi (Department of Molecular Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Kobayashi Makoto (Department of Molecular Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Tamaki Motoyuki (Diabetes Therapeutics Research Center, Tokushima University) ,  Sato Youichi (Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Fukui Hiroyuki (Department of Molecular Studies for Incurable Diseases, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Yamauchi Aiko (Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School)
Material： Journal of Medical Investigation (Web)  (J Med Invest (Web))
Volume： 64  Issue： 1.2  Page： 122-128(J-STAGE)  Publication year： 2017 
JST Material Number： U0711A  ISSN： 1349-6867  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *protein kinase C ,...
Semi thesaurus term： *Protein Kinase C-delta ,...

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Author keywords (4)： glucagon secretion ,  pancreatic α-cells ,  PKCδ ,  streptozotocin-induced diabetic mice

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Basic medicine on endocrine system  (GL01020Q)

Reference (34)：

• 1. Ahrén B, Landin-Olsson M, Jansson PA, Svensson M, Holmes D, Schweizer A: Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. J Clin Endocrinol Metab 89: 2078-2084, 2004
• 2. Hare KJ, Vilsbøll T, Asmar M, Deacon CF, Knop FK, Holst JJ: The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. Diabetes 59: 1765-1770, 2010
• 3. Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ: Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 494: 256-260, 2013
• 4. Raskin P, Unger RH: Effect of insulin therapy on the profiles of plasma immunoreactive glucagon in juvenile-type and adult-type diabetics. Diabetes 27: 411-419, 1978
• 5. Kielgast U, Holst JJ, Madsbad S: Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function. Diabetes 60: 1599-1607, 2011

Terms in the title (5)： 蛋白質キナーゼCδ ,  シグナル伝達 ,  膵島 ,  グルカゴン ,  分泌