Art

J-GLOBAL ID：201702259868106352   Reference number：17A0177464

Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor

板藍根の成分であるインジルビンはヒトプレグナンX受容体を介してCYP3A4遺伝子転写を活性化する

Author (8)： Kumagai Takeshi (Department of Environmental Health Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan) ,  Aratsu Yusuke (Department of Environmental Health Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan) ,  Aratsu Yusuke (Drug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan) ,  Sugawara Ryosuke (Department of Environmental Health Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan) ,  Sasaki Takamitsu (Department of Environmental Health Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan) ,  Sasaki Takamitsu (Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan) ,  Miyairi Shinichi (Laboratory of Organic Chemistry, School of Pharmacy, Nihon University, 7-7-1 Narashino, Funabashi, Chiba 274-8555, Japan) ,  Nagata Kiyoshi (Department of Environmental Health Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan)
Material： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metab Pharmacokinet (Web))
Volume： 31  Issue： 2  Page： 139-145  Publication year： Apr. 2016 
JST Material Number： U0705A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *medicinal plant ,...
Semi thesaurus term： *板藍根 ,...

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Author keywords (5)： AhR activator ,  Indirubin ,  CYP3A4 induction ,  PXR ,  Herb-drug interactions

JST classification (3)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Research methods in genetics  (EC01020N) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (2)： Indirubin ,  Rifampin

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• Ho YL, Chang YS. Studies on the antinociceptive, anti-inflammatory and anti pyretic effects of Isatis indigotica root. Phytomedicine 2002;9:419-24.
• Honda G, Tosirisuk V, Tabata M. Isolation of an antidermatophytic, tryptanthrin, from indigo plants, Polygonum tinctorium and Isatis tinctoria. Planta Med 1980;38:275-6.

Terms in the title (8)： 藍 ,  根 ,  インジルビン ,  ヒト ,  プレグナンX受容体 ,  CYP3A4遺伝子 ,  転写 ,  活性化