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J-GLOBAL ID：201702262350821296   Reference number：17A1466776

Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact

締付内皮細胞-細胞接触による腫瘍におけるリゾホスファチジン酸受容体4活性化はドラッグデリバリー【Powered by NICT】

Author (17)： Takara Kazuhiro (Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Takara Kazuhiro (Research Unit/Frontier Therapeutic Sciences Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000 Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan) ,  Eino Daisuke (Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Eino Daisuke (Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ando Koji (Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan) ,  Yasuda Daisuke (Department of Immunology, Akita University Graduate School of Medicine, Akita University, Akita 010-8543, Japan) ,  Naito Hisamichi (Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Tsukada Yohei (Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Iba Tomohiro (Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Wakabayashi Taku (Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Muramatsu Fumitaka (Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Kidoya Hiroyasu (Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan) ,  Fukuhara Shigetomo (Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan) ,  Mochizuki Naoki (Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan) ,  Ishii Satoshi (Department of Immunology, Akita University Graduate School of Medicine, Akita University, Akita 010-8543, Japan) ,  Kishima Haruhiko (Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Takakura Nobuyuki (Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan)
Material： Cell Reports
Volume： 20  Issue： 9  Page： 2072-2086  Publication year： 2017 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Vascular normalization in tumo...

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Thesaurus term： *tumor ,  tumor immunity ,  cadherin ,  therapy ,  angiogenesis inhibitor ,  *endothelial cell ,  cell membrane ,  *drug delivery system ,  anoxia ,  actin ,  vascular permeability ,  blood vessel ,  angiogenesis ,  antitumor drug
Semi thesaurus term： VE-カドヘリン , 【Automatic Indexing@JST】

Author keywords (5)： angiogenesis ,  LPA ,  LPA4 ,  drug delivery ,  VE-cadherin

JST classification (4)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Cell physiology in general  (EF02010S) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Basic biopharmacy  (GY01021U)

Terms in the title (7)： 締付 ,  内皮細胞 ,  細胞接触 ,  腫瘍 ,  リゾホスファチジン酸受容体 ,  活性化 ,  ドラッグデリバリー