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J-GLOBAL ID：201702262408221575   Reference number：17A1098454

Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway

肥満および2型糖尿病における不均衡なインシュリン作用:インスリンシグナル伝達経路の重要なマウスモデル【Powered by NICT】

Author (10)： Kubota Tetsuya (Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Kubota Tetsuya (Laboratory for Metabolic Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Kubota Tetsuya (Clinical Nutrition Program, National Institute of Health and Nutrition, Tokyo 162-8636, Japan) ,  Kubota Tetsuya (Translational Systems Biology and Medicine Initiative (TSBMI), The University of Tokyo, Tokyo 153-8515, Japan) ,  Kubota Naoto (Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Kubota Naoto (Laboratory for Metabolic Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan) ,  Kubota Naoto (Clinical Nutrition Program, National Institute of Health and Nutrition, Tokyo 162-8636, Japan) ,  Kubota Naoto (Translational Systems Biology and Medicine Initiative (TSBMI), The University of Tokyo, Tokyo 153-8515, Japan) ,  Kadowaki Takashi (Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan) ,  Kadowaki Takashi (Translational Systems Biology and Medicine Initiative (TSBMI), The University of Tokyo, Tokyo 153-8515, Japan)
Material： Cell Metabolism
Volume： 25  Issue： 4  Page： 797-810  Publication year： 2017 
JST Material Number： W3108A  ISSN： 1550-4131  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Since the discovery of the tyr...

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Thesaurus term： knockout mouse ,  tyrosine kinase ,  *type 2 diabetes mellitus ,  *diabetes mellitus ,  human(primates) ,  down-regulation ,  pathophysiology ,  *insulin ,  insulin resistance ,  insulin receptor ,  *obesity
Semi thesaurus term： *インスリンシグナル ,  IRS1 ,  *マウスモデル ,  *インスリン作用 , 【Automatic Indexing@JST】

Author keywords (10)： insulin actions ,  insulin resistance ,  obesity ,  diabetes ,  selective insulin resistance ,  insulin receptor ,  insulin receptor substrate ,  insulin signaling ,  mouse models ,  fatty liver

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Cell physiology in general  (EF02010S)

Terms in the title (6)： 肥満 ,  2型糖尿病 ,  インシュリン作用 ,  インスリン ,  シグナル伝達経路 ,  マウスモデル