Art

J-GLOBAL ID：201702262558142387   Reference number：17A1003596

Simulation of ventricular rate control during atrial fibrillation using ionic channel blockers

イオンチャンネル遮断薬を用いた心房細動時の心拍数コントロールのシミュレーション

Author (10)： Inada Shin (Himeji Dokkyo University, Himeji, Hyogo, Japan) ,  Shibata, MD, PhD Nitaro (Shinjuku Mitsui Building Clinic, Tokyo, Japan) ,  Iwata, PhD Michiaki (Japan Agency for Medical Research and Development, Tokyo, Japan) ,  Haraguchi, PhD Ryo (Graduate School of Applied Informatics, University of Hyogo, Kobe, Hyogo, Japan) ,  Ashihara MD, PhD Takashi (Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan) ,  Ikeda, MD, PhD Takanori (Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan) ,  Mitsui, PhD Kazuyuki (Graduate School of Advanced Science and Technology, Tokyo Denki University, Tokyo, Japan) ,  Dobrzynski, PhD Halina (Institute of Cardiovascular Medicine, University of Manchester, Manchester, United Kingdom) ,  Boyett, PhD Mark R. (Institute of Cardiovascular Medicine, University of Manchester, Manchester, United Kingdom) ,  Nakazawa, PhD Kazuo (National Cerebral and Cardiovascular Center, Suita, Osaka, Japan)
Material： Journal of Arrhythmia (Web)
Volume： 33  Issue： 4  Page： 302-309  Publication year： 2017 
JST Material Number： U1150A  ISSN： 1880-4276  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： computer simulation ,...
Semi thesaurus term： Right atrium ,...

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Author keywords (5)： Atrial fibrillation ,  Arrhythmia ,  Ventricular rate control ,  Cardiac conduction system ,  Computer simulation

JST classification (3)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of cardioactive drugs  (GW07020N) ,  Medical information processing  (JE15030Q)

Reference (20)：

• Boyett MR, Honjo H, Kodama I. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc Res 2000;47:658-87. http://dx.doi.org/10.1016/S0008-6363(00)00135-8.
• Li J, Greener ID, Inada S, et al. Computer three-dimensional reconstruction of the atrioventricular node. Circ Res 2008;102:975-85. http://dx.doi.org/10.1161/CIRCRESAHA.108.172403.
• The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med 2002;347:1825-33.
• Greener ID, Monfredi O, Inada S, et al. Molecular architecture of the human specialised atrioventricular conduction axis. J Mol Cell Cardiol 2011;50:642- 51. http://dx.doi.org/10.1016/j.yjmcc.2010.12.017.
• Yang T, Snyders DJ, Roden DM. Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K⁺ current (I_Kr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation 1995;91:1799-806. http://dx.doi.org/10.1161/01.CIR.91.6.1799.

Terms in the title (6)： イオンチャンネル ,  遮断薬 ,  心房細動 ,  心拍数 ,  コントロール ,  シミュレーション