Art

J-GLOBAL ID：201702263420882837   Reference number：17A1481092

IBMX protects human proximal tubular epithelial cells from hypoxic stress through suppressing hypoxia-inducible factor-1α expression

IBMXは低酸素誘導因子 1α発現の抑制を介して低酸素ストレスからのヒト近位尿細管上皮細胞を保護する【Powered by NICT】

Author (12)： Hasan Arif Ul (Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Kita-gun, Miki-cho, Kagawa 761-0793, Japan) ,  Hasan Arif Ul (Department of Pharmacology, Faculty of Medicine, International University of Health and Welfare, 4-2, Kojunomori, Narita-shi, Chiba 286-8686, Japan) ,  Kittikulsuth Wararat (Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Kita-gun, Miki-cho, Kagawa 761-0793, Japan) ,  Yamaguchi Fuminori (Department of Cell Physiology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Kita-gun, Miki-cho, Kagawa 761-0793, Japan) ,  Musarrat Ansary Tuba (Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Kita-gun, Miki-cho, Kagawa 761-0793, Japan) ,  Rahman Asadur (Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Kita-gun, Miki-cho, Kagawa 761-0793, Japan) ,  Rahman Asadur (Department of Pharmacology, Faculty of Medicine, International University of Health and Welfare, 4-2, Kojunomori, Narita-shi, Chiba 286-8686, Japan) ,  Shibayama Yuki (Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Kita-gun, Miki-cho, Kagawa 761-0793, Japan) ,  Nakano Daisuke (Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Kita-gun, Miki-cho, Kagawa 761-0793, Japan) ,  Hitomi Hirofumi (Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Kita-gun, Miki-cho, Kagawa 761-0793, Japan) ,  Tokuda Masaaki (Department of Cell Physiology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Kita-gun, Miki-cho, Kagawa 761-0793, Japan) ,  Nishiyama Akira (Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Kita-gun, Miki-cho, Kagawa 761-0793, Japan)
Material： Experimental Cell Research  (Exp Cell Res)
Volume： 358  Issue： 2  Page： 343-351  Publication year： 2017 
JST Material Number： B0313A  ISSN： 0014-4827  CODEN： ECREAL  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Hypoxia predisposes renal fibr...

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Thesaurus term： Cell Death ,  Proteins ,  promoter (genetics) ,  *oxygen deficiency ,  mRNA ,  Western blotting ,  luciferase ,  fibrous disease ,  Down-Regulation ,  *human ,  binding site ,  anoxia ,  Hypoxia-Inducible Factor 1, alpha Subunit ,  bioassay ,  adenine nucleotide ,  ribonucleotide ,  cyclic nucleotide
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Kidney disease ,  Renal fibrosis ,  Phosphodiesterase inhibitor ,  cAMP ,  Protein kinase A

JST classification (3)： Function of cell components  (EF03060C) ,  Cell components in general  (EF03010Z) ,  Cell physiology in general  (EF02010S)

Substance index (1)： cAMP

Terms in the title (6)： IBMX ,  低酸素誘導因子 ,  発現 ,  低酸素ストレス ,  ヒト ,  近位尿細管上皮細胞