Art
J-GLOBAL ID：201702263919803068   Reference number：17A1431501

MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by exacerbating radiation-induced aberrant mitosis

新規Chk1阻害剤MK8776は悪化させる放射線誘発異常有糸分裂によるUCN-01に比べて改良された放射線増感作用を示す【Powered by NICT】
Author (5)：
Suzuki Motofumi

About Suzuki Motofumi

(Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan)

About Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan

, 
Yamamori Tohru

About Yamamori Tohru

(Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan)

About Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan

, 
Bo Tomoki

About Bo Tomoki

(Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan)

About Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan

, 
Sakai Yuri

About Sakai Yuri

(Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan)

About Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan

, 
Inanami Osamu

About Inanami Osamu

(Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan)

About Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan


Material：
Translational Oncology

About Translational Oncology


Volume： 10  Issue： 4  Page： 491-500  Publication year： 2017 
JST Material Number： W2898A  ISSN： 1936-5233  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
All summary is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
Checkpoint kinase 1 (Chk1) is ...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*radioactive ray

About radioactive ray

, 
DNA double strand break

About DNA double strand break

, 
serine-threonine kinase

About serine-threonine kinase

, 
*Mitosis

About Mitosis

, 
*radiosensitization

About radiosensitization

, 
Cell Death

About Cell Death

, 
Centrosome

About Centrosome

, 
*radiosensitization effect

About radiosensitization effect

, 
spindle (cytology)

About spindle (cytology)

, 
cytotoxicity

About cytotoxicity

, 
*checkpoint kinase 1

About checkpoint kinase 1


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
チェックポイント

About チェックポイント

, 
生細胞イメージング

About 生細胞イメージング

, 
*阻害剤

About 阻害剤

, 【Automatic Indexing@JST】
JST classification (2)：
JST classification
Category name(code) classified by JST.
Cell physiology in general 
(EF02010S)

About Cell physiology in general

,  Basic research of antitumor(=antineoplastic)drugs 
(GW16010A)

About Basic research of antitumor(=antineoplastic)drugs

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
UCN-01

About UCN-01

Terms in the title (8)：
Terms in the title
Keywords automatically extracted from the title.
Chk1

About Chk1

, 
阻害剤

About 阻害剤

, 
悪化

About 悪化

, 
放射線

About 放射線

, 
誘発

About 誘発

, 
有糸分裂

About 有糸分裂

, 
UCN-01

About UCN-01

, 
放射線増感作用

About 放射線増感作用


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